Reproductive role of prolactin

被引：150

作者：

Bachelot, Anne

Binart, Nadine ^{[1
]}

机构：

[1] INSERM, U809, Paris, France

[2] Univ Paris 05, Fac Med Rene Descartes, Paris, France

[3] Grp Hosp Pitie Salpetriere, APHP, Dept Endocrinol & Reprod Med, F-75634 Paris, France

来源：

REPRODUCTION | 2007年 / 133卷 / 02期

关键词：

D O I：

10.1530/REP-06-0299

中图分类号：

Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

The biological actions of prolactin (PRL), a polypeptide hormone, are mostly related to lactation and reproduction. These actions have been clarified by studies of PRL and PRL-deficient receptor mice, which have a clear phenotype of reproductive failure at multiple sites. This review aims to summarize current knowledge about PRL and its receptor, role in reproductive axis and presents information of hyperprolactinemia in reproductive medicine. Our understanding of the physiology and transduction pathway of PRL has largely increased in the past 20 years with the cloning of PRL and its receptor gene.

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收藏

页码：361 / 369

页数：9

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