A simple and efficient method for synthesis of 5-substituted 2′-deoxyuridine nucleosides using metal- halogen exchange reaction of 5-iodo-2′-deoxyuridine sodium salt

被引：12

作者：

Aso, M ^{[1
]}

Kaneko, T ^{[1
]}

Nakamura, M ^{[1
]}

Koga, N ^{[1
]}

Suemune, H ^{[1
]}

机构：

[1] Kyushu Univ, Grad Sch Pharmaceut Sci, Fukuoka 8128582, Japan

来源：

CHEMICAL COMMUNICATIONS | 2003年 / 09期

关键词：

D O I：

10.1039/b301425h

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Treatment of the sodium salt of 2'-deoxy-3', 5'-bis-O-(tert-nbutyldimethylsilyl)5-iodouridine ( 3) with n-BuLi effected regioselective lithiation at the 5-position and the following reaction with various electrophiles afforded 5-substituted 2'-deoxyuridines including 1b, the precursor of stable spin-labeled 1a, in good yields.

引用

页码：1094 / 1095

页数：2

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