Molecular remission of Philadelphia/bcr-abl-positive acute myeloid leukaemia after treatment with anti-CD33 calicheamicin conjugate (gemtuzumab ozogamicin, CMA-676)

被引：15

作者：

de Vetten, MP

Jansen, JH

van der Reijden, BA

Berger, MS

Zijlmans, JMJM

Löwenberg, B

机构：

[1] Univ Rotterdam Hosp, Daniel den Hoed Klin, Dept Haematol, NL-3008 AE Rotterdam, Netherlands

[2] Wyeth Ayerst Res, Dept Clin Res & Dev, Radnor, PA USA

来源：

BRITISH JOURNAL OF HAEMATOLOGY | 2000年 / 111卷 / 01期

关键词：

acute myeloid leukaemia; gemtuzumab ozogamicin (CMA-676);

D O I：

10.1046/j.1365-2141.2000.02402.x

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

The anti-CD33 monoclonal antibody linked to NAc-gamma calicheamicin gemtuzumab ozogamicin (CMA-676) was used to treat a patient with Philadelphia/bcr-abl-positive acute myeloid leukaemia, We report a morphological and cytogenetic complete remission after treatment with two doses of gemtuzumab ozogamicin as a single agent, Using real-time polymerase chain reaction (PCR), gemtuzumab ozogamicin treatment resulted in a 3-log tumour mass reduction in bone marrow.

引用

页码：277 / 279

页数：3

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