Preliminary investigation of the association of oral lichen planus and hepatitis C

被引：71

作者：

Bagan, JV ^{[1
]}

Ramon, C ^{[1
]}

Gonzalez, L ^{[1
]}

Diago, M ^{[1
]}

Milian, MA ^{[1
]}

Cors, R ^{[1
]}

Lloria, E ^{[1
]}

Cardona, F ^{[1
]}

Jimenez, Y ^{[1
]}

机构：

[1] Univ Valencia, Gen Hosp, Valencia, Spain

来源：

ORAL SURGERY ORAL MEDICINE ORAL PATHOLOGY ORAL RADIOLOGY AND ENDODONTOLOGY | 1998年 / 85卷 / 05期

关键词：

D O I：

10.1016/S1079-2104(98)90286-4

中图分类号：

R78 [口腔科学];

学科分类号：

1003 ;

摘要：

Objective. The aim of this investigation was to determine if an association exists between hepatitis C virus and oral lichen planus. Study Design. Three groups of subjects were selected: 505 patients with hepatitis C virus infection (group 1), 100 patients with oral lichen planus (group 2), and a randomly selected control group (age-and gender-matched) of 100 healthy subjects (group 3). The prevalence of oral lichen planus was determined in groups 1 and 3, and the prevalence of hepatitis C virus infection was established in groups 2 and 3. Results. The prevalence of oral lichen planus was 3.36% (n = 17) in group 1 and 1% (n = 1) in the control group; the prevalence of hepatitis C virus infection was 23% (n = 23) in group 2, and 5% (n = 5) in the control group. No significant differences were observed in the incidence of oral lichen planus in group 1 between those patients who received interferon and those who did not. The 17 patients in group 1 who manifested oral lichen planus and hepatitis C virus infection simultaneously exhibited a marked tendency to have only reticular lesions (70.6%), with involvement of the buccal mucosa in 88.2% of these patients, the tongue in 29.4%, and the gingiva in 11.8%. Analyzing a randomized subgroup of 143 patients from group 1 (subgroup 1) that was matched by age and gender with groups 2 and 3, we found that the incidence of oral lichen planus in patients with hepatitis C virus infection (subgroup 1) was greater than in the control group (5.59% vs 1%), though this was not statistically significant (chi(2) = 0.119; p = 0.06). In contrast, group 2 exhibited a statistically significant higher incidence of hepatitis C virus infection (23%) than the controls (5%; chi(2) = 0.259, p = 0.0002). Conclusions. The prevalence of hepatitis C virus infection in patients with oral lichen planus was greater than in the control series. In our opinion this observation warrants the investigation of potential concomitant hepatitis C virus infection in patients with oral lichen planus.

引用

页码：532 / 536

页数：5

共 56 条

[1]

AGNER T, 1992, ACTA DERM-VENEREOL, V72, P380

[2] PRELIMINARY REPORT ON PREVALENCES OF ORAL MUCOSAL LESIONS IN A SWEDISH POPULATION [J].