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The retinoblastoma protein pathway in cell cycle control and cancer

被引：220
作者：
Bartek, J [1 ]
Bartkova, J [1 ]
Lukas, J [1 ]
机构：
[1] Danish Canc Soc, Inst Canc Biol, DK-2100 Copenhagen, Denmark
来源：
EXPERIMENTAL CELL RESEARCH | 1997年 / 237卷 / 01期
关键词：
D O I：
10.1006/excr.1997.3776
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Recent discoveries in diverse fields of biomedical research have merged to reveal the molecular basis of cell cycle control and a critical role of subverting this homeostatic mechanism in cancer development. At the heart of these processes lies a late G1 checkpoint governed by the "RB pathway" whose molecular composition, functions, and cancer-associated defects are briefly evaluated in this review. This exciting new knowledge raises a plethora of conceptual issues in cell biology, with potential practical implications for biotechnology and medicine. (C) 1997 Academic Press.
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页码：1 / 6
页数：6
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