High power laser production of short-lived isotopes for positron emission tomography

被引：119

作者：

Ledingham, KWD ^{[1
]}

McKenna, P

McCanny, T

Shimizu, S

Yang, JM

Robson, L

Zweit, J

Gillies, JM

Bailey, J

Chimon, GN

Clarke, RJ

Neely, D

Norreys, PA

Collier, JL

Singhal, RP

Wei, MS

Mangles, SPD

Nilson, P

Krushelnick, K

Zepf, M

机构：

[1] Univ Strathclyde, Dept Phys, Glasgow G4 0NG, Lanark, Scotland

[2] UMIST, Christie Hosp NHS Trust, Paterson Inst Canc Res, CR UK, Manchester M20 4BX, Lancs, England

[3] Rutherford Appleton Lab, Cent Laser Facil, CCLRC, Didcot OX11 0QX, Oxon, England

[4] Univ Glasgow, Dept Phys & Astron, Glasgow G12 8QQ, Lanark, Scotland

[5] Univ London Imperial Coll Sci Technol & Med, Blackett Lab, London SW7 2BZ, England

[6] Queens Univ Belfast, Dept Pure & Appl Phys, Belfast B17 1NN, Antrim, North Ireland

来源：

JOURNAL OF PHYSICS D-APPLIED PHYSICS | 2004年 / 37卷 / 16期

关键词：

D O I：

10.1088/0022-3727/37/16/019

中图分类号：

O59 [应用物理学];

学科分类号：

摘要：

Positron emission tomography (PET) is a powerful diagnostic/imaging technique requiring the production of the short-lived positron emitting isotopes C-11, N-13, O-15 and F-18 by proton irradiation of natural/enriched targets using cyclotrons. The development of PET has been hampered due to the size and shielding requirements of nuclear installations. Recent results show that when an intense laser beam interacts with solid targets, megaelectronvolt (MeV) protons capable of producing PET isotopes are generated. This report describes how to generate intense PET sources of C-11 and F-18 using a petawatt laser beam. The work describing the laser production of F-18 through a (p,n) O-18 reaction, and the subsequent synthesis of 2-[F-18] is reported for the first time. The potential for developing compact laser technology for this purpose is discussed.

引用

页码：2341 / 2345

页数：5

共 20 条

[1] Measurements of energetic proton transport through magnetized plasma from intense laser interactions with solids [J].

Clark, EL ;

Krushelnick, K ;

Davies, JR ;

Zepf, M ;

Tatarakis, M ;

Beg, FN ;

Machacek, A ;

Norreys, PA ;

Santala, MIK ;

Watts, I ;

Dangor, AE .

PHYSICAL REVIEW LETTERS, 2000, 84 (04) :670-673

[2]

COLLIER JL, COMMUNICATION

[3] POWERFUL FEMTOSECOND PULSE GENERATION BY CHIRPED AND STRETCHED PULSE PARAMETRIC AMPLIFICATION IN BBO CRYSTAL [J].

DUBIETIS, A ;

JONUSAUSKAS, G ;

PISKARSKAS, A .

OPTICS COMMUNICATIONS, 1992, 88 (4-6) :437-440

[4] Proposed double-layer target for the generation of high-quality laser-accelerated ion beams [J].

Esirkepov, TZ ;

Bulanov, SV ;

Nishihara, K ;

Tajima, T ;

Pegoraro, F ;

Khoroshkov, VS ;

Mima, K ;

Daido, H ;

Kato, Y ;

Kitagawa, Y ;

Nagai, K ;

Sakabe, S .

PHYSICAL REVIEW LETTERS, 2002, 89 (17) :175003/1-175003/4

[5] Proton beams generated with high-intensity lasers:: Applications to medical isotope production [J].

Fritzler, S ;

Malka, V ;

Grillon, G ;

Rousseau, JP ;

Burgy, F ;

Lefebvre, E ;

d'Humières, E ;

McKenna, P ;

Ledingham, KWD .

APPLIED PHYSICS LETTERS, 2003, 83 (15) :3039-3041

[6]

HAMACHER K, 1986, J NUCL MED, V27, P235

[7] Electron, photon, and ion beams from the relativistic interaction of Petawatt laser pulses with solid targets [J].

Hatchett, SP ;

Brown, CG ;

Cowan, TE ;

Henry, EA ;

Johnson, JS ;

Key, MH ;

Koch, JA ;

Langdon, AB ;

Lasinski, BF ;

Lee, RW ;

Mackinnon, AJ ;

Pennington, DM ;

Perry, MD ;

Phillips, TW ;

Roth, M ;

Sangster, TC ;

Singh, MS ;

Snavely, RA ;

Stoyer, MA ;

Wilks, SC ;

Yasuike, K .

PHYSICS OF PLASMAS, 2000, 7 (05) :2076-2082

[8] Applications for nuclear phenomena generated by ultra-intense lasers [J].

Ledingham, KWD ;

McKenna, P ;

Singhal, RP .

SCIENCE, 2003, 300 (5622) :1107-1111

[9] Electron acceleration by a wake field forced by an intense ultrashort laser pulse [J].

Malka, V ;

Fritzler, S ;

Lefebvre, E ;

Aleonard, MM ;

Burgy, F ;

Chambaret, JP ;

Chemin, JF ;

Krushelnick, K ;

Malka, G ;

Mangles, SPD ;

Najmudin, Z ;

Pittman, M ;

Rousseau, JP ;

Scheurer, JN ;

Walton, B ;

Dangor, AE .

SCIENCE, 2002, 298 (5598) :1596-1600

[10]

NAKAMURA KG, 2004, FIHFP2004 INT WORKSH

← 1 2 →