The Effects of Repetitive Transcranial Magnetic Stimulation in Patients with Chronic Schizophrenia: Insights from EEG Microstates

被引：32

作者：

Pan, Zhilin ^{[1
,3
,5
]}

Xiong, Dongsheng ^{[1
,3
,5
]}

Xiao, Huisi ^{[1
,3
,5
]}

Li, Jiahui ^{[1
,3
,5
]}

Huang, Yuanyuan ^{[2
,3
]}

Zhou, Jing ^{[1
,3
,5
]}

Chen, Jun ^{[4
,7
]}

Li, Xiaobo ^{[9
]}

Ning, Yuping ^{[2
,3
]}

Wu, Fengchun ^{[2
,3
]}

Wu, Kai ^{[1
,2
,3
,4
,5
,6
,7
,8
]}

机构：

[1] South China Univ Technol, Sch Mat Sci & Engn, Dept Biomed Engn, Guangzhou 510006, Peoples R China

[2] Guangzhou Med Univ, Guangzhou Huiai Hosp, Affiliated Brain Hosp, Guangzhou 510370, Peoples R China

[3] Guangdong Engn Technol Res Ctr Translat Med Menta, Guangzhou 510370, Peoples R China

[4] Guangdong Engn Technol Res Ctr Diag & Rehabil Dem, Guangzhou 510500, Peoples R China

[5] South China Univ Technol, Natl Engn Res Ctr Tissue Restorat & Reconstruct, Guangzhou 510006, Peoples R China

[6] South China Univ Technol, Key Lab Biomed Engn Guangdong Prov, Guangzhou 510006, Peoples R China

[7] Natl Engn Res Ctr Healthcare Devices, Guangzhou 510500, Peoples R China

[8] Tohoku Univ, Inst Dev Aging & Canc, Dept Nucl Med & Radiol, Sendai, Miyagi 9808575, Japan

[9] New Jersey Inst Technol, Dept Biomed Engn, Newark, NJ 07102 USA

来源：

PSYCHIATRY RESEARCH | 2021年 / 299卷

基金：

中国国家自然科学基金;

关键词：

Chronic schizophrenia; EEG microstate; rTMS; left DLPFC; PANSS; DORSOLATERAL PREFRONTAL CORTEX; PREDOMINANT NEGATIVE SYMPTOMS; RESTING-STATE NETWORKS; ELECTROPHYSIOLOGICAL SIGNATURES; MAP SERIES; BRAIN; RTMS; HYPOFRONTALITY; NAIVE; CONNECTIVITY;

D O I：

10.1016/j.psychres.2021.113866

中图分类号：

R749 [精神病学];

学科分类号：

100204 [神经病学];

摘要：

The objective of this study was to investigate the effects of 10 Hz repetitive transcranial magnetic stimulation (rTMS) in patients with schizophrenia using EEG microstates. Thirty-eight patients with chronic schizophrenia were included in a double-blind, randomized and sham-controlled trial (19 participants in the active group and 19 participants in the sham group) and received 10 Hz active or sham rTMS stimulation to the left dorsolateral prefrontal cortex (left DLPFC) 5 days per week over for 4 weeks. Four classical microstate classes (i.e., classes A, B, C and D) were identified by clustering, and the parameters (i.e., duration, occurrence and contribution) of each class were computed. Our results showed that (1) after stimulation, the positive and negative syndrome scale (PANSS) positive scores decreased significantly in the active group; (2) the duration of the microstate of class C derived from EEG data decreased significantly in the active group; and (3) the change of the duration of class D in the active group was significantly higher than that in the sham group. Our findings demonstrated that 10 Hz active rTMS stimulation was beneficial to improving the positive symptoms of patients with chronic schizophrenia, and the EEG microstate could be an effective indicator of symptom improvements.

引用

页数：8

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