Improved resolution of magnetic resonance microscopy in examination of skin tumors

Magnetic resonance imaging has become increasingly important for visualization and tissue differentiation of internal organs, Because of limited resolution, investigation of skin has been of little diagnostic value so far. We combined a homogeneous magnetic field of 9.4 T, as used in magnetic resonance spectroscopy, with gradient fields of 11.7 G/cm and an imaging unit to obtain a voxel resolution of 40 x 40 x 300 mu m(3). With this magnetic resonance microscopy unit, we studied normal skin, 12 nevocellular nevi, 20 basal cell carcinomas, 8 melanomas, and 8 seborrheic keratoses after excision in vitro, The specimens were visualized in spin-echo images. The proton relaxation times T1 and T2 were determined for the different skin layers and tumor tissues, interpretation of the spin-echo images was based on comparison with the correlating histology, Epidermis, dermis, subcutaneous tissue, and hair follicle complexes could be distinguished, Stratum corneum and hairs emitted no signal, All tumors presented as distinct, signal-rich, homogeneous structures within the dark, signal-poor dermis, Their shape corresponded to their outline in the histologic sections, Buds of superficial basal cell carcinomas could be resolved, The proton relaxation times T1 and T2 were significantly different among all skin layers and tumors, Our results demonstrate that with sufficient resolution, differentiation of skin tumors is possible using magnetic resonance imaging.