Synthesis and antibacterial activity of 4,5,6,7-tetrahydro-thieno[3,2-c]pyridine quinolones

被引：64

作者：

Srivastava, Brijesh Kumar ^{[1
]}

Solanki, Manish ^{[1
]}

Mishra, Bhupendra ^{[1
]}

Soni, Rina ^{[1
]}

Jayadev, Sanjaya ^{[1
]}

Valan, Darshan ^{[1
]}

Jain, Mulcul ^{[1
]}

Patel, Pankaj R. ^{[1
]}

机构：

[1] Sarkhej Bavla NH, Zydus Res Ctr, Ahmadabad, Gujarat 382210, India

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2007年 / 17卷 / 07期

关键词：

4,5,6,7-tetrahydro-thieno[3,2-c]pyridine; quinolone antibacterial agent; in vitro MIC assay; gram-positive organism; linezolid resistant staphylococcus aureus;

D O I：

10.1016/j.bmcl.2007.01.038

中图分类号：

R914 [药物化学];

学科分类号：

100701 [药物化学];

摘要：

Synthesis and antibacterial activity of a number of substituted 4,5,6,7-tetrahydro-thieno[3,2-c]pyridine quinolones is reported. The antibacterial activities were evaluated in standard in vitro MIC assay method. Some of the compounds showed in vitro (MIC) antibacterial activity comparable to those of Gatifloxacin, Ciprofloxacin, and Sparfloxacin. (c) 2007 Elsevier Ltd. All rights reserved.

引用

页码：1924 / 1929

页数：6

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