Hematopoietic Stem Cell Transplantation for MDS

被引：34

作者：

Bartenstein, Matthias ^{[1
]}

Deeg, H. Joachim ^{[1
,2
]}

机构：

[1] Fred Hutchinson Canc Res Ctr, Div Clin Res, Seattle, WA 98109 USA

[2] Univ Washington, Dept Med, Sch Med, Seattle, WA 98195 USA

来源：

HEMATOLOGY-ONCOLOGY CLINICS OF NORTH AMERICA | 2010年 / 24卷 / 02期

关键词：

Transplantation for MDS; Conditioning intensity; Cytogenetics and relapse; ACUTE MYELOID-LEUKEMIA; BONE-MARROW-TRANSPLANTATION; CORD BLOOD TRANSPLANTATION; ACUTE MYELOGENOUS LEUKEMIA; NONMYELOABLATIVE ALLOGENEIC TRANSPLANTATION; PRETRANSPLANTATION SERUM FERRITIN; IDENTICAL SIBLING DONORS; VERSUS-HOST-DISEASE; INDEX HCT-CI; MYELODYSPLASTIC SYNDROMES;

D O I：

10.1016/j.hoc.2010.02.003

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 [肿瘤学];

摘要：

Hematopoietic stem cell transplantation (HSCT) offers potentially curative therapy for patients with myelodysplastic syndromes (MDS). However, as the majority of patients with MDS are in the seventh or eighth decade of life, conventional transplant regimens have been used only infrequently, and only with the development of reduced-intensity conditioning has transplantation been applied more broadly to older patients. Dependent upon disease status at the time of transplantation, 30% to 70% of patients can be expected to be cured of their disease and survive long term. However, posttransplant relapse and graft-versus-host disease (GVHD) remain problems and further investigations are needed.

引用

页码：407 / +

页数：17

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