Immunization with alpha-toxin toxoid protects the cornea against tissue damage during experimental Staphylococcus aureus keratitis

被引：39

作者：

Hume, EBH

Dajcs, JJ

Moreau, JM

O'Callaghan, RJ

机构：

[1] Louisiana State Univ, Hlth Sci Ctr, Dept Microbiol Immunol & Parasitol, New Orleans, LA 70112 USA

[2] Louisiana State Univ, Ctr Eye, Dept Ophthalmol, New Orleans, LA 70112 USA

来源：

INFECTION AND IMMUNITY | 2000年 / 68卷 / 10期

关键词：

D O I：

10.1128/IAI.68.10.6052-6055.2000

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Alpha-toxin is a major virulence factor in Staphylococcus aureus keratitis. Active or passive immunization with alpha-toxin toroid could protect against corneal damage. Results show that either form of immunization did not kill bacteria but did significantly protect against corneal pathology, especially epithelial erosion.

引用

收藏

页码：6052 / 6055

页数：4

相关论文

共 28 条

[1] EFFECT OF IMMUNIZATION WITH HIGHLY PURIFIED ALPHA-TOXINS AND BETA-TOXINS ON STAPHYLOCOCCAL MASTITIS IN RABBITS [J].

ADLAM, C ;

WARD, PD ;

MCCARTNEY, AC ;

ARBUTHNOTT, JP ;

THORLEY, CM .

INFECTION AND IMMUNITY, 1977, 17 (02) :250-256

[2]

ARVIDSON SO, 1983, STAPHYLOCOCCI STAPHY, P745

[3] ULCERATIVE KERATITIS - SURVEY OF 30 YEARS LABORATORY EXPERIENCE [J].

ASBELL, P ;

STENSON, S .

ARCHIVES OF OPHTHALMOLOGY, 1982, 100 (01) :77-80

[4]

BERNHEIMER AW, 1988, METHOD ENZYMOL, V165, P213

[5] PRODUCTION AND CHARACTERIZATION OF MONOCLONAL-ANTIBODIES AGAINST STAPHYLOCOCCUS-AUREUS ALPHA-TOXIN [J].

BLOMQVIST, L ;

SJOGREN, AM .

TOXICON, 1988, 26 (03) :265-273

[6] CORNEAL VIRULENCE OF STAPHYLOCOCCUS-AUREUS - ROLES OF ALPHA-TOXIN AND PROTEIN-A IN PATHOGENESIS [J].

CALLEGAN, MC ;

ENGEL, LS ;

HILL, JM ;

OCALLAGHAN, RJ .

INFECTION AND IMMUNITY, 1994, 62 (06) :2478-2482

[7]

*CDCP, 1999, MMWR-MORBID MORTAL W, V32, P707

[8] Discovering the neural basis of human social anxiety: A diagnostic and therapeutic imperative [J].

Charney, DS .

AMERICAN JOURNAL OF PSYCHIATRY, 2004, 161 (01) :1-2

[9] COMPARISON OF ENTEROTOXINS AND HEMOLYSINS PRODUCED BY METHICILLIN-RESISTANT (MRSA) AND SENSITIVE (MSSA) STAPHYLOCOCCUS-AUREUS [J].

COIA, JE ;

BROWNING, L ;

HAINES, L ;

BIRKBECK, TH ;

PLATT, DJ .

JOURNAL OF MEDICAL MICROBIOLOGY, 1992, 36 (03) :164-171

[10] A Staphylococcus aureus capsular polysaccharide (CP) vaccine and CP-specific antibodies protect mice against bacterial challenge [J].

Fattom, AI ;

Sarwar, J ;

Ortiz, A ;

Naso, R .

INFECTION AND IMMUNITY, 1996, 64 (05) :1659-1665