Human leukocyte antigen class I and II alleles in non-Hodgkin lymphoma etiology

被引：64

作者：

Wang, Sophia S. ^{[1
]}

Abdou, Amr M. ^{[2
]}

Morton, Lindsay M. ^{[3
]}

Thomas, Rasmi ^{[2
]}

Cerhan, James R. ^{[4
]}

Gao, Xiaojiang ^{[2
]}

Cozen, Wendy ^{[5
]}

Rothman, Nathaniel ^{[3
]}

Davis, Scott ^{[6
,7
]}

Severson, Richard K. ^{[8
,9
]}

Bernstein, Leslie

Hartge, Patricia ^{[3
]}

Carrington, Mary ^{[2
,10
,11
]}

机构：

[1] City Hope Natl Med Ctr, Beckman Res Inst, Dept Populat Sci, Div Canc Etiol, Duarte, CA 91010 USA

[2] NCI Frederick, Canc & Inflammat Program, Expt Immunol Lab, SAIC Frederick Inc, Frederick, MD USA

[3] NCI, Div Canc Epidemiol & Genet, NIH, Rockville, MD USA

[4] Mayo Clin, Coll Med, Rochester, MN USA

[5] Univ So Calif, Norris Comprehens Canc Ctr, Los Angeles, CA USA

[6] Fred Hutchinson Canc Res Ctr, Seattle, WA 98104 USA

[7] Univ Washington, Seattle, WA 98195 USA

[8] Wayne State Univ, Dept Family Med & Publ Hlth Sci, Detroit, MI USA

[9] Karmanos Canc Inst, Detroit, MI USA

[10] MIT, Massachusetts Gen Hosp, Ragon Inst, Boston, MA USA

[11] Harvard Univ, Boston, MA 02115 USA

来源：

BLOOD | 2010年 / 115卷 / 23期

关键词：

CHRONIC HEPATITIS-B; NECROSIS-FACTOR TNF; HETEROZYGOTE ADVANTAGE; INTERLYMPH-CONSORTIUM; GENETIC-VARIANTS; RISK; HLA; ASSOCIATION; SUSCEPTIBILITY; POLYMORPHISMS;

D O I：

10.1182/blood-2010-01-266775

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Genome-wide association and candidate gene studies implicate different genetic variants within the 6p21 chromosomal region with different non-Hodgkin lymphoma (NHL) subtypes. Complementing these efforts, we conducted human leukocyte antigen (HLA) class I and class II genotyping among 610 NHL cases and 555 controls of non-Hispanic white descent from a US multicenter study. Allele-disease associations were assessed by logistic regression for NHL and its subtypes. Statistically significant associations between HLA and NHL subtypes include HLA-DRB1*0101 for follicular lymphoma (odds ratio [OR] = 2.14, P < .001), HLA-DRB1*0401 for diffuse large B-cell lymphoma (DLBCL; OR = 0.45, P = .006), and HLA-DRB1*13 and follicular lymphoma (OR = 0.48, P = .008). We further observed significant heterozygote advantage for HLA class I alleles and NHL, and particularly DLBCL (P trend = .01 for elevated risk with increasing number of homozygous alleles). Our results support a role for HLA in the etiology of NHL and its subtypes. (Blood. 2010;115(23):4820-4823)

引用

页码：4820 / 4823

页数：4

共 20 条

[1] Human leukocyte antigen (HLA) A1-B8-DR3 (8.1) haplotype, tumor necrosis factor (TNF) G-308A, and risk of non-Hodgkin lymphoma [J].

Abdou, A. M. ;

Gao, X. ;

Cozen, W. ;

Cerhan, J. R. ;

Rothman, N. ;

Martin, M. P. ;

Davis, S. ;

Schenk, M. ;

Chanock, S. J. ;

Hartge, P. ;

Carrington, M. ;

Wang, S. S. .

LEUKEMIA, 2010, 24 (05) :1055-1058

[2] HLA and HIV-1:: Heterozygote advantage and B*35-Cw*04 disadvantage [J].

Carrington, M ;

Nelson, GW ;

Martin, MP ;

Kissner, T ;

Vlahov, D ;

Goedert, JJ ;

Kaslow, R ;

Buchbinder, S ;

Hoots, K ;

O'Brien, SJ .

SCIENCE, 1999, 283 (5408) :1748-1752

[3] A high-resolution HLA and SNP haplotype map for disease association studies in the extended human MHC [J].

de Bakker, Paul I. W. ;

McVean, Gil ;

Sabeti, Pardis C. ;

Miretti, Marcos M. ;

Green, Todd ;

Marchini, Jonathan ;

Ke, Xiayi ;

Monsuur, Alienke J. ;

Whittaker, Pamela ;

Delgado, Marcos ;

Morrison, Jonathan ;

Richardson, Angela ;

Walsh, Emily C. ;

Gao, Xiaojiang ;

Galver, Luana ;

Hart, John ;

Hafler, David A. ;

Pericak-Vance, Margaret ;

Todd, John A. ;

Daly, Mark J. ;

Trowsdale, John ;

Wijmenga, Cisca ;

Vyse, Tim J. ;

Beck, Stephan ;

Murray, Sarah Shaw ;

Carrington, Mary ;

Gregory, Simon ;

Deloukas, Panos ;

Rioux, John D. .

NATURE GENETICS, 2006, 38 (10) :1166-1172

[4] ENHANCED IMMUNOLOGICAL SURVEILLANCE IN MICE HETEROZYGOUS AT H-2 GENE COMPLEX [J].

DOHERTY, PC ;

ZINKERNAGEL, RM .

NATURE, 1975, 256 (5512) :50-52

[5] MHC class II genes influence the susceptibility to chronic active hepatitis C [J].

Hohler, T ;

Gerken, G ;

Notghi, A ;

Knolle, P ;

Lubjuhn, R ;

Taheri, H ;

Schneider, PM ;

zumBuschenfelde, KHM ;

Rittner, C .

JOURNAL OF HEPATOLOGY, 1997, 27 (02) :259-264

[6] HLA-DRB1*1301 and *1302 protect against chronic hepatitis B [J].

Hohler, T ;

Gerken, G ;

Notghi, A ;

Lubjuhn, R ;

Taheri, H ;

Protzer, U ;

Lohr, HF ;

Schneider, PM ;

zumBuschenfelde, KHM ;

Rittner, C .

JOURNAL OF HEPATOLOGY, 1997, 26 (03) :503-507

[7] Association of HLA-DRB1*13 and TNF-α gene polymorphisms with clearance of chronic hepatitis B infection and risk of hepatocellular carcinoma in Thai population [J].

Kummee, P. ;

Tangkijvanich, P. ;

Poovorawan, Y. ;

Hirankarn, N. .

JOURNAL OF VIRAL HEPATITIS, 2007, 14 (12) :841-848

[8] Influence of HLA haplotypes on the clinical courses of individuals infected with hepatitis C virus [J].

Kuzushita, N ;

Hayashi, N ;

Moribe, T ;

Katayama, K ;

Kanto, T ;

Nakatani, S ;

Kaneshige, T ;

Tatsumi, T ;

Ito, A ;

Mochizuki, K ;

Sasaki, Y ;

Kasahara, A ;

Hori, M .

HEPATOLOGY, 1998, 27 (01) :240-244

[9] HLA class II associated risk and protection against multiple sclerosis -: a Finnish family study [J].

Laaksonen, M ;

Pastinen, T ;

Sjöroos, M ;

Kuokkanen, S ;

Ruutiainen, J ;

Sumelahti, ML ;

Reijonen, H ;

Salonen, R ;

Wikström, J ;

Panelius, M ;

Partanen, J ;

Tienari, PJ ;

Ilonen, J .

JOURNAL OF NEUROIMMUNOLOGY, 2002, 122 (1-2) :140-145

[10] Cutting edge: Heterozygote advantage in autoimmune disease: Hierarchy of protection/susceptibility conferred by HLA and killer Ig-like receptor combinations in psoriatic arthritis [J].

Nelson, GW ;

Martin, MP ;

Gladman, D ;

Wade, J ;

Trowsdale, J ;

Carrington, M .

JOURNAL OF IMMUNOLOGY, 2004, 173 (07) :4273-4276

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