Influenza virus-infected epithelial cells present viral antigens to antigen-specific CD8+ cytotoxic T lymphocytes

被引：22

作者：

Nguyen, HH ^{[1
]}

Boyaka, PN

Moldoveanu, Z

Novak, MJ

Kiyono, H

McGhee, JR

Mestecky, J

机构：

[1] Univ Alabama, Dept Microbiol, Birmingham, AL 35294 USA

[2] Univ Alabama, Immunobiol Vaccine Ctr, Birmingham, AL 35294 USA

[3] Osaka Univ, Microbial Dis Res Inst, Dept Mucosal Immun, Suita, Osaka 565, Japan

来源：

JOURNAL OF VIROLOGY | 1998年 / 72卷 / 05期

关键词：

D O I：

10.1128/JVI.72.5.4534-4536.1998

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

We have investigated the mechanisms involved in the clearance of viral infection at the epithelium level by analyzing the activity of influenza virus-specific cytotoxic T lymphocytes (CTL) against virus-infected CMT-93 intestinal epithelial cells. Epithelial cells infected with live influenza virus effectively present viral antigens and were lysed by both homotypic and heterotypic influenza virus-specific CD8(+) T cells. These results shed new light on the control of viral infection through the elimination of virus-infected epithelial cells by virus-specific CTL and demonstrate that CMT-93 cells furnish an appropriate model for in vitro evaluation of CTL activity against virus-infected epithelial cells.

引用

页码：4534 / 4536

页数：3

共 24 条

[1] INDUCTION OF HOMOTYPIC AND HETEROTYPIC T-CELL AND B-CELL IMMUNITY WITH INFLUENZA-A VIRUS IN MICE [J].

ARMERDING, D ;

LIEHL, E .

CELLULAR IMMUNOLOGY, 1981, 60 (01) :119-135

[2] ROLE OF VIRAL INFECTIVITY IN INDUCTION OF INFLUENZA VIRUS-SPECIFIC CYTOTOXIC T-CELLS [J].

BRACIALE, TJ ;

YAP, KL .

JOURNAL OF EXPERIMENTAL MEDICINE, 1978, 147 (04) :1236-1252

[3]

GLATHE H, 1984, ACTA VIROL, V28, P287

[4]

HARDING CV, 1994, IMMUNOLOGY, V83, P670

[5] CLEARANCE OF SENDAI VIRUS BY CD8(+) T-CELLS REQUIRES DIRECT TARGETING TO VIRUS-INFECTED EPITHELIUM [J].

HOU, S ;

DOHERTY, PC .

EUROPEAN JOURNAL OF IMMUNOLOGY, 1995, 25 (01) :111-116

[6] THE HEMAGGLUTININS OF DUCK AND HUMAN H1 INFLUENZA-VIRUSES DIFFER IN SEQUENCE CONSERVATION AND IN GLYCOSYLATION [J].

INKSTER, MD ;

HINSHAW, VS ;

SCHULZE, IT .

JOURNAL OF VIROLOGY, 1993, 67 (12) :7436-7443

[7] Specificity of human cytotoxic T lymphocytes induced by a human papillomavirus type 16 E7-derived peptide [J].

Jochmus, I ;

Osen, W ;

Altmann, A ;

Buck, G ;

Hofmann, B ;

Schneider, A ;

Gissmann, L ;

Rammensee, HG .

JOURNAL OF GENERAL VIROLOGY, 1997, 78 :1689-1695

[8] BIOLOGICAL PROPERTIES OF AN INFLUENZA-A VIRUS-SPECIFIC KILLER T-CELL CLONE - INHIBITION OF VIRUS-REPLICATION INVIVO AND INDUCTION OF DELAYED-TYPE HYPERSENSITIVITY REACTIONS [J].

LIN, YL ;

ASKONAS, BA .

JOURNAL OF EXPERIMENTAL MEDICINE, 1981, 154 (02) :225-234

[9] CYTO-TOXIC T-CELL IMMUNITY TO INFLUENZA [J].

MCMICHAEL, AJ ;

GOTCH, FM ;

NOBLE, GR ;

BEARE, PAS .

NEW ENGLAND JOURNAL OF MEDICINE, 1983, 309 (01) :13-17

[10] Immunological ignorance of an E7-encoded cytolytic T-lymphocyte epitope in transgenic mice expressing the E7 and E6 oncogenes of human papillomavirus type 16 [J].

Melero, I ;

Singhal, MC ;

McGowan, P ;

Haugen, HS ;

Blake, J ;

Hellstrom, KE ;

Yang, GC ;

Clegg, CH ;

Chen, LP .

JOURNAL OF VIROLOGY, 1997, 71 (05) :3998-4004

← 1 2 3 →