Agonists at μ-opioid receptors spin the wheels to keep the action going

被引：6

作者：

Cox, BM ^{[1
]}

机构：

[1] Uniformed Serv Univ Hlth Sci, Dept Pharmacol, Bethesda, MD 20814 USA

来源：

MOLECULAR PHARMACOLOGY | 2005年 / 67卷 / 01期

关键词：

D O I：

10.1124/mol.104.008433

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

A study in this issue of Molecular Pharmacology on agonist-induced internalization of mu-opioid receptors during long-term opiate drug exposure is discussed. The study demonstrates the critical role of re-cycling of reactivated mu receptors back to the plasma membrane for the maintenance of agonist signaling during long-term opiate exposure.

引用

页码：12 / 14

页数：3

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