Diet-induced obesity and mammary tumor development in MMTV-neu female mice

被引:48
作者
Cleary, MP
Grande, JP
Juneja, SC
Maihle, NJ
机构
[1] Univ Minnesota, Hormel Inst, Austin, MN 55912 USA
[2] Mayo Clin & Mayo Fdn, Dept Lab Med & Pathol, Rochester, MN 55905 USA
[3] Mayo Clin & Mayo Fdn, Dept Biochem & Mol Biol, Rochester, MN 55905 USA
来源
NUTRITION AND CANCER-AN INTERNATIONAL JOURNAL | 2004年 / 50卷 / 02期
关键词
D O I
10.1207/s15327914nc5002_7
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
Obesity is a risk factor for postmenopausal breast cancer and is associated with shortened latency and/or increased mammary tumor (MT) incidence in animals. Elevated body weight is usually associated with hormone-responsive tumors. In agreement with these data we previously showed that latency of hormone-responsive MTs in MMTV-TGF-alpha mice with diet-induced obesity was significantly shortened. Here, we used the same protocol to determine the impact of diet-induced obesity on estrogen receptor-negative MT development in MMTV-neu (strain 202) mice. Mice were fed a low-fat diet (n = 20) or a high-fat diet (n = 54) from 10 wk of age. Body weight at 19 wk of age was used to assign high-fat mice to obesity-prone, overweight, and obesity-resistant groups. Mice were euthanized due to MT size or at 85 wk of age. Final body weights of obesity-prone mice were heaviest, and those of obesity-resistant and low-fat groups were similar Fat pad weights were heaviest in obesity-prone mice followed by overweight and obesity- resistant groups, and lightest in low-fat mice. Serum IGF-I levels were similar for low-fat and high-fat mice, whereas leptin was higher in high-fat mice (P < 0.0001). MT latency, incidence, metastasis, and burden were similar for all groups. These findings support that obesity is not a risk factor for development of estrogen-negative breast cancer.
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收藏
页码:174 / 180
页数:7
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