The SNM1/Pso2 Family of ICL Repair Nucleases: From Yeast to Man

被引：38

作者：

Cattell, Emma ^{[1
]}

Sengerova, Blanka ^{[1
]}

McHugh, Peter J. ^{[1
]}

机构：

[1] Univ Oxford, Weatherall Inst Mol Med, John Radcliffe Hosp, Oxford OX3 9DS, England

来源：

ENVIRONMENTAL AND MOLECULAR MUTAGENESIS | 2010年 / 51卷 / 06期

关键词：

interstrand crosslink; SNM1; PSO2; metallo-beta-lactamase domain; nucleotide excision repair; homologous recombination; translesion synthesis; nuclease; METALLO-BETA-LACTAMASE; INTERSTRAND CROSS-LINKS; DOUBLE-STRAND BREAKS; NORMAL CELLULAR-RESPONSE; S-PHASE CHECKPOINT; DNA-DAMAGE; CRYSTAL-STRUCTURE; HUMAN TELOMERES; FANCONI-ANEMIA; RADIATION RAD;

D O I：

10.1002/em.20556

中图分类号：

X [环境科学、安全科学];

学科分类号：

083001 [环境科学];

摘要：

Efficient interstrand crosslink (ICL) repair in yeast depends on the Pso2/Snm1 protein. Pso2 is a member of the highly conserved metallo-beta-lactamase structural family of nucleases. Mammalian cells possess three SNM1/Pso2 related proteins, SNM1A, SNM1B/Apollo, and SNM1C/Artemis. Evidence that SNM1A and SNM1B contribute to ICL repair is mounting, whereas Artemis appears to primarily contribute to non-ICL repair pathways, particularly some double-strand break repair events. Yeast Pso2 and all three mammalian SNM1-family proteins have been shown to possess nuclease activity. Here, we review the biochemical, genetic, and cellular evidence for the SNM1 family as DNA repair factors, focusing on ICL repair. Environ. Mol. Mutagen. 51:635-645, 2010. (C) 2010 Wiley-Liss, Inc

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页码：635 / 645

页数：11

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