Nuclear dots:: Actors on many stages

被引:124
作者
Sternsdorf, T [1 ]
Grötzinger, T [1 ]
Jensen, K [1 ]
Will, H [1 ]
机构
[1] Univ Hamburg, Heinrich Pette Inst Expt Virol & Immunol, D-2000 Hamburg, Germany
关键词
D O I
10.1016/S0171-2985(97)80051-4
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
Nuclear dots (NDs), alternatively designated nuclear bodies (NBs), PML oncogenic domains (PODs), nuclear domain 10 (ND10) or Kr-bodies, became a major topic for researchers in many fields only recently. Originally described as an autoantigenic target in patients with primary biliary cirrhosis, they are now also known to play a role in development of acute promyelocytic leukemia (APL) and possibly other forms of neoplasia. Size, number and composition of NDs are regulated throughout the cell cycle. Infection with herpes simplex virus, adenovirus, cytomegalovirus, Epstein-Barr-virus, influenza virus and human T cell lymphotropic virus type I (HTLV I) strongly modifies ND structure through viral regulatory proteins. Due to this finding and because at least three of the cellular Nn proteins are highly interferon-inducible, a function of NDs in early viral infection or in antiviral response has been postulated. Functional data are currently available only for two of the ND-associated proteins. The Sp100 protein seems to have transcriptional transactivating property, whereas the promyelocytic leukemia protein (PML) was reported to suppress growth and transformation. Here, we give a brief overview of the data currently available on NDs. Thus, we hope to link seemingly unrelated findings in the literature on oncology, virology, cell biology, and immunology.
引用
收藏
页码:307 / 331
页数:25
相关论文
共 129 条
  • [1] EVOLUTION OF A LONG-RANGE REPEAT FAMILY IN CHROMOSOME-1 OF THE GENUS MUS
    AGULNIK, S
    PLASS, C
    TRAUT, W
    WINKING, H
    [J]. MAMMALIAN GENOME, 1993, 4 (12) : 704 - 710
  • [2] AHN MJ, 1995, ONCOGENE, V10, P2307
  • [3] A retrovirus carrying the promyelocyte-retinoic acid receptor PML-RAR alpha fusion gene transforms haematopoietic progenitors in vitro and induces acute leukaemias
    Altabef, M
    Garcia, M
    Lavau, C
    Bae, SC
    Dejean, A
    Samarut, J
    [J]. EMBO JOURNAL, 1996, 15 (11) : 2707 - 2716
  • [4] CHROMOSOMAL ORGANIZATION OF THE HUMAN DIHYDROFOLATE-REDUCTASE GENES - DISPERSION, SELECTIVE AMPLIFICATION, AND A NOVEL FORM OF POLYMORPHISM
    ANAGNOU, NP
    OBRIEN, SJ
    SHIMADA, T
    NASH, WG
    CHEN, MJ
    NIENHUIS, AW
    [J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA-BIOLOGICAL SCIENCES, 1984, 81 (16): : 5170 - 5174
  • [5] HUMAN AUTOANTIBODY TO A NOVEL PROTEIN OF THE NUCLEAR COILED BODY - IMMUNOLOGICAL CHARACTERIZATION AND CDNA CLONING OF P80-COILIN
    ANDRADE, LEC
    CHAN, EKL
    RASKA, I
    PEEBLES, CL
    ROOS, G
    TAN, EM
    [J]. JOURNAL OF EXPERIMENTAL MEDICINE, 1991, 173 (06) : 1407 - 1419
  • [6] A FAMILY OF TRANSCRIPTIONAL ADAPTER PROTEINS TARGETED BY THE E1A ONCOPROTEIN
    ARANY, Z
    NEWSOME, D
    OLDREAD, E
    LIVINGSTON, DM
    ECKNER, R
    [J]. NATURE, 1995, 374 (6517) : 81 - 84
  • [7] IDENTIFICATION OF A NOVEL NUCLEAR DOMAIN
    ASCOLI, CA
    MAUL, GG
    [J]. JOURNAL OF CELL BIOLOGY, 1991, 112 (05) : 785 - 795
  • [8] STRUCTURE OF THE C3HC4 DOMAIN BY H-1-NUCLEAR MAGNETIC-RESONANCE SPECTROSCOPY - A NEW STRUCTURAL CLASS OF ZINC-FINGER
    BARLOW, PN
    LUISI, B
    MILNER, A
    ELLIOTT, M
    EVERETT, R
    [J]. JOURNAL OF MOLECULAR BIOLOGY, 1994, 237 (02) : 201 - 211
  • [9] BERNSTEIN RM, 1984, CLIN EXP IMMUNOL, V55, P553
  • [10] Identification and characterization of a leukocyte-specific component of the nuclear body
    Bloch, DB
    delaMonte, SM
    Guigaouri, P
    Filippov, A
    Bloch, KD
    [J]. JOURNAL OF BIOLOGICAL CHEMISTRY, 1996, 271 (46) : 29198 - 29204