The latency-associated nuclear antigen of Kaposi's sarcoma-associated herpesvirus permits replication of terminal repeat-containing plasmids

被引：118

作者：

Grundhoff, A

Ganem, D ^{[1
]}

机构：

[1] Univ Calif San Francisco, Med Ctr, Howard Hughes Med Inst, Dept Microbiol, San Francisco, CA 94143 USA

[2] Univ Calif San Francisco, Med Ctr, Howard Hughes Med Inst, Dept Med, San Francisco, CA 94143 USA

来源：

JOURNAL OF VIROLOGY | 2003年 / 77卷 / 04期

关键词：

D O I：

10.1128/JVI.77.4.2779-2783.2003

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

The latency-associated nuclear antigen (LANA) of Kaposi's sarcoma-associated herpesvirus can associate with mitotic chromosomes and promote latent episome maintenance and segregation. Here we report that LANA also mediates the replication of plasmid DNAs bearing viral terminal repeats. The predicted secondary structure of LANA's C terminus reveals striking similarity to the known structure of the DNA-binding domain of Epstein-Barr virus EBNA1, despite the absence of primary sequence homology between these proteins, suggesting conservation of the key mechanistic features of latent gammaherpesvirus DNA replication.

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页码：2779 / 2783

页数：5

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