Self-poisoning with lamotrigine and pregabalin

被引:29
作者
Braga, A. J. [1 ]
Chidley, K. [1 ]
机构
[1] Gloucestershire Royal Hosp, Dept Anaesthet & Intens Care, Gloucester GL1 3NN, England
关键词
D O I
10.1111/j.1365-2044.2006.04913.x
中图分类号
R614 [麻醉学];
学科分类号
100217 [麻醉学];
摘要
We report a case of intentional overdose in a 29-year-old male with two of the newer anti-epileptic agents, lamotrigine and pregabalin. To our knowledge, this case report details the highest plasma levels of lamotrigine ever recorded in the literature. The patient presented with seizures and a reduced level of consciousness. Management of these and subsequent complications centres on supportive care in the high dependency and intensive therapy units.
引用
收藏
页码:524 / 527
页数:4
相关论文
共 18 条
[1]
BURSTEIN AH, 1995, PHARMACOTHERAPY, V15, P129
[2]
Committee on Safety of Medicines and Medicines Control Agency, 2000, CURRENT PROBLEMS PHA, V26, P4
[3]
Dollery C., 1999, THERAPEUTIC DRUGS
[4]
Fishbain D A, 1999, Semin Clin Neuropsychiatry, V4, P221
[5]
Characterization of gabapentin overdose using a poison center case series [J].
Klein-Schwartz, W ;
Shepherd, JG ;
Gorman, S ;
Dahl, B .
JOURNAL OF TOXICOLOGY-CLINICAL TOXICOLOGY, 2003, 41 (01) :11-15
[6]
Evaluation of lamotrigine toxicity reported to poison centers [J].
Lofton, AL ;
Klein-Schwartz, W .
ANNALS OF PHARMACOTHERAPY, 2004, 38 (11) :1811-1815
[7]
Lamotrigine and therapeutic drug monitoring: retrospective survey following the introduction of a routine service [J].
Morris, RG ;
Black, AB ;
Harris, AL ;
Batty, AB ;
Sallustio, BC .
BRITISH JOURNAL OF CLINICAL PHARMACOLOGY, 1998, 46 (06) :547-551
[8]
Bipolar disorder [J].
Müller-Oerlinghausen, B ;
Berghöfer, A ;
Bauer, M .
LANCET, 2002, 359 (9302) :241-247
[9]
Risk factors for suicide in epilepsy:: A case control study [J].
Nilsson, L ;
Ahlbom, A ;
Farahmand, BY ;
Åsberg, M ;
Tomson, T .
EPILEPSIA, 2002, 43 (06) :644-651
[10]
Lamotrigine overdose in an adult [J].
O'Donnell, J ;
Bateman, DN .
JOURNAL OF TOXICOLOGY-CLINICAL TOXICOLOGY, 2000, 38 (06) :659-660