Hypofractionation in adjuvant breast radiotherapy

被引：10

作者：

Khan, Atif ^{[1
]}

Haffty, Bruce G. ^{[1
]}

机构：

[1] Univ Med & Dent New Jersey, Robert Wood Johnson Med Sch, Dept Radiat Oncol, Canc Inst New Jersey, New Brunswick, NJ 08901 USA

来源：

BREAST | 2010年 / 19卷 / 03期

关键词：

Breast cancer; Hypofractionation; Radiation therapy; Toxicity; Radiobiology; RANDOMIZED-TRIAL; RADIATION-THERAPY; UK STANDARDIZATION; CANCER; FRACTIONATION; IRRADIATION; BOOST; WOMEN;

D O I：

10.1016/j.breast.2010.03.004

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 [肿瘤学];

摘要：

Altered fractionation for whole breast irradiation has been extensively studied over the past 20 years, with recent updated publications from several landmark randomized trials. In this review, the radiobiological principles underlying altered fractionation schedules are reviewed, and outcomes, including local control, acute and chronic toxicities from the major published studies are summarized. While the studies published to date provide strong clinical evidence demonstrating acceptable results with hypofractionated regimens, there remain many unanswered questions. The current status of hypofractionated radiation and future directions for research are discussed. (C) 2010 Elsevier Ltd. All rights reserved.

引用

页码：168 / 171

页数：4

共 19 条

[1]

THE USE OF A SPECIFIC HYPOFRACTIONATED RADIATION-THERAPY REGIMEN VERSUS CLASSICAL FRACTIONATION IN THE TREATMENT OF BREAST-CANCER - A RANDOMIZED STUDY OF 230 PATIENTS [J].