Botryorhodines A-D, antifungal and cytotoxic depsidones from Botryosphaeria rhodina, an endophyte of the medicinal plant Bidens pilosa

被引：78

作者：

Abdou, Randa ^{[1
]}

Scherlach, Kirstin ^{[1
]}

Dahse, Hans-Martin ^{[1
]}

Sattler, Isabel ^{[1
]}

Hertweck, Christian ^{[1
,2
]}

机构：

[1] HKI, Leibniz Inst Nat Prod Res & Infect Biol, D-07745 Jena, Germany

[2] Univ Jena, Jena, Germany

来源：

PHYTOCHEMISTRY | 2010年 / 71卷 / 01期

关键词：

Antifungal agents; Depsidones; Botryosphaeria rhodina; Endophytes; Polyketides; Symbiosis; BACTERIAL ENDOPHYTES; LICHEN; ACID; METABOLITES; IDENTIFICATION; INHIBITION;

D O I：

10.1016/j.phytochem.2009.09.024

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

070307 [化学生物学]; 071010 [生物化学与分子生物学];

摘要：

An endophytic fungus (Botryosphaeria rhodina) was isolated from the stems of the medicinal plant Bidens pilosa (Asteraceae) that is known for its anti-inflammatory, antiseptic and antifungal effects. The ethyl acetate extract of the fungal isolate exhibits significant antifungal activity as well as potent cytotoxic and antiproliferative effects against several cancer cell lines. Activity-guided fractionation resulted in the isolation of a complex of four depsidones, botryorhodines A-D and the auxin indole carboxylic acid. Botryorhodine A and B show moderate to weak cytotoxic activities against HeLa cell lines with a CC50 Of 96.97 mu M and 36.41 mu M, respectively. In addition, they also show antifungal activity against a range of pathogenic fungi such as Aspergillus terreus (MIC 26.03 mu M for botryorhodine A and 49.70 mu M for B) and the plant pathogen Fusarium oxysporum (MIC 191.60 mu M for botryorhodine A and 238.80 mu M for B). A potential role of the endophyte in modulating fungal populations living within or attacking the host plant is discussed. (C) 2009 Elsevier Ltd. All rights reserved.

引用

页码：110 / 116

页数：7

共 41 条

[1]

4-Fluorophenylglycine as a label for 19F NMR structure analysis of membrane-associated peptides [J].

Afonin, S ;

Glaser, RW ;

Berditchevskaia, M ;

Wadhwani, P ;

Gührs, KH ;

Möllmann, U ;

Perner, A ;

Ulrich, AS .

CHEMBIOCHEM, 2003, 4 (11) :1151-1163

[2]

Cytotoxic activity of compounds from the lichen: Cladonia convoluta [J].

Bézivin, C ;

Tomasi, S ;

Rouaud, I ;

Delcros, JG ;

Boustie, J .

PLANTA MEDICA, 2004, 70 (09) :874-877

[3]

INTERACTIONS BETWEEN INFECTION BY ENDOPHYTIC FUNGI AND NUTRIENT LIMITATION IN THE GRASSES LOLIUM-PERENNE AND FESTUCA-ARUNDINACEA [J].

CHEPLICK, GP ;

CLAY, K ;

MARKS, S .

NEW PHYTOLOGIST, 1989, 111 (01) :89-97

[4]

Herbicidal and fungicidal activities and identification of potential phytotoxins from Bidens pilosa L. var. radiata Scherff [J].

Deba, Farah ;

Xuan, Tran Dang ;

Yasuda, Masaaki ;

Tawata, Shinkichi .

WEED BIOLOGY AND MANAGEMENT, 2007, 7 (02) :77-83

[5]

Stictic acid derivatives from the lichen Usnea articulata and their antioxidant activities [J].

Devehat, Françoise Lohézic-Le ;

Tomasi, Sophie ;

Elix, John A. ;

Bernard, Aurélie ;

Rouaud, Isabelle ;

Uriac, Philippe ;

Boustie, Joël .

JOURNAL OF NATURAL PRODUCTS, 2007, 70 (07) :1218-1220

[6]

N-Benzylsalicylthioamides: Highly Active Potential Antituberculotics [J].

Dolezal, Rafael ;

Waisser, Karel ;

Petrlikova, Eva ;

Kunes, Jiri ;

Kubicova, Lenka ;

Machacek, Milos ;

Kaustova, Jarmila ;

Dahse, Hans Martin .

ARCHIV DER PHARMAZIE, 2009, 342 (02) :113-119

[7]

Sublobaric acid and oxolobaric acid, two new depsidones from the lichen Anzia hypoleucoides [J].

Elix, JA ;

Wardlaw, JH ;

Yoshimura, I .

AUSTRALIAN JOURNAL OF CHEMISTRY, 1997, 50 (07) :763-765

[8]

METABOLITES FROM THE LICHEN GENUS PSOROMA [J].

ELIX, JA ;

LAJIDE, L ;

GALLOWAY, DJ .

AUSTRALIAN JOURNAL OF CHEMISTRY, 1982, 35 (11) :2325-2333

[9]

The structure of chalybaeizanic acid and quaesitic acid, two new lichen depsidones related to salazinic acid [J].

Elix, JA ;

Wardlaw, JH .

AUSTRALIAN JOURNAL OF CHEMISTRY, 1999, 52 (07) :713-715

[10]

NEW DEPSIDONES FROM THE LICHEN GENUS ERIODERMA [J].

ELIX, JA ;

JENIE, UA ;

ARVIDSSON, L ;

JORGENSEN, PM ;

JAMES, PW .

AUSTRALIAN JOURNAL OF CHEMISTRY, 1986, 39 (04) :719-722

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