A general synthetic method for the formation of substituted 5-aminotetrazoles from thioureas: A strategy for diversity amplification

被引：127

作者：

Batey, RA ^{[1
]}

Powell, DA ^{[1
]}

机构：

[1] Univ Toronto, Lash Miller Chem Labs, Dept Chem, Toronto, ON M5S 3H6, Canada

来源：

ORGANIC LETTERS | 2000年 / 2卷 / 20期

关键词：

D O I：

10.1021/ol006465b

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

[GRAPHICS] A general method for the synthesis of 5 aminotetrazoles is outlined using the mercury(ll)-promoted attack of azide anion on a thiourea. The reaction proceeds through a guanyl azide intermediate, which undergoes electrocyclization to the tetrazole. The method is high yielding and provides access to mono-, di-, and trisubstituted 5-aminotetrazoles, targets of potential interest for combinatorial library development.

引用

页码：3237 / 3240

页数：4

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