Insulin-like growth factor binding protein-1 (IGFBP-1): a multifunctional role in the human female reproductive tract

被引：87

作者：

Fowler, DJ

Nicolaides, KH

Miell, JP

机构：

[1] Kings Coll Hosp London, Dept Obstet & Gynaecol, Harris Birthright Res Ctr Fetal Med, London, England

[2] Guys Kings & St Thomas Med Sch, Dept Med, London, England

来源：

HUMAN REPRODUCTION UPDATE | 2000年 / 6卷 / 05期

基金：

英国惠康基金;

关键词：

female reproductive tract; IGFBP-1; intrauterinegrowth restriction; polycystic ovarian syndrome; pre-eclampsia;

D O I：

10.1093/humupd/6.5.495

中图分类号：

R71 [妇产科学];

学科分类号：

100211 ;

摘要：

Insulin-like growth factor-1 (IGFBP-1) is particularly important in human female reproductive physiology, where it is involved with other factors in a complex system which regulates menstrual cycles, puberty, ovulation, decidualization, implantation and fetal growth. This has implications for clinical obstetrics and gynaecology, where there is evidence for a pathophysiological role for IGPBP-1 in pre-eclampsia, intrauterine growth restriction, polycystic ovarian syndrome and trophoblast and endometrial neoplasms.

引用

收藏

页码：495 / 504

页数：10

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