A novel thiourea ligand applied in the Pd-catalyzed Heck, Suzuki and Suzuki carbonylative reactions

被引：89

作者：

Dai, MJ

Liang, B

Wang, CH

You, ZJ

Xiang, J

Dong, GB

Chen, JH

Yang, Z ^{[1
]}

机构：

[1] Peking Univ, Key Lab Bioorgan Chem & Mol Engn, Minist Educ, Coll Chem, Beijing 100871, Peoples R China

[2] Peking Univ, Shenzhen Grad Sch, Lab Chem Genet, Univ Town 518055, Shenzhen, Peoples R China

[3] VivoQuest Inc, Valley Cottage, NY 10989 USA

来源：

ADVANCED SYNTHESIS & CATALYSIS | 2004年 / 346卷 / 13-15期

关键词：

cross-coupling; Heck reaction; palladium; Suzuki reaction; thiourea;

D O I：

10.1002/adsc.200404165

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

A novel C-2 symmetrical and sterically bulky thiourea ligand 1 has been successfully applied to Heck, Suzuki and Suzuki-type carbonylative coupling reactions under aerobic conditions. Since the metal-sulfur bond in the thiourea complexes is stronger than the metal-phosphorus bond of typical phosphine complexes, thiourea ligands generally do not easily dissociate from the metal center under catalytic conditions, which establishes the thiourea 1-based palladium complexes as effective catalysts for the palladium-catalyzed cross-coupling reactions.

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页码：1669 / 1673

页数：5

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