Highly enantioselective addition of diethylzinc to diphenylphosphinoyl imines under dual amino alcohol/halosilane mediation

被引：62

作者：

Jimeno, C ^{[1
]}

Reddy, KS ^{[1
]}

Solà, L ^{[1
]}

Moyano, A ^{[1
]}

Pericàs, MA ^{[1
]}

Riera, A ^{[1
]}

机构：

[1] Univ Barcelona, Dept Quim Organ, Unitat Rec Sintesi Asimetr, E-08028 Barcelona, Spain

来源：

ORGANIC LETTERS | 2000年 / 2卷 / 20期

关键词：

D O I：

10.1021/ol006354c

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

[GRAPHICS] Arylethylene derived, enantiomerically pure amino alcohols have been evaluated as ligands for the dual-catalyzed (amino alcohol/halosilane) enantioselective addition of diethylzinc to diphenylphosphinoyl imines. Among them, the conformationally restricted g-fluorenone derived ligand 4c provides the highest enantioselectivities so far reported over a range of substrate imines.

引用

页码：3157 / 3159

页数：3

共 21 条

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