Induced Pluripotent Stem Cells in Dermatology: Potentials, Advances, and Limitations

被引：16

作者：

Bilousova, Ganna ^{[1
,2
]}

Roop, Dennis R. ^{[1
,2
]}

机构：

[1] Univ Colorado, Dept Dermatol, Aurora, CO 80045 USA

[2] Univ Colorado, Charles C Gates Ctr Regenerat Med & Stem Cell Bio, Aurora, CO 80045 USA

来源：

COLD SPRING HARBOR PERSPECTIVES IN MEDICINE | 2014年 / 4卷 / 11期

基金：

美国国家卫生研究院;

关键词：

JUNCTIONAL EPIDERMOLYSIS-BULLOSA; SOMATIC-CELLS; DYSKERATOSIS-CONGENITA; REVERTANT MOSAICISM; SENDAI-VIRUS; GENETIC CORRECTION; TELOMERE DYNAMICS; HUMAN FIBROBLASTS; TARGETING DNA; BONE-MARROW;

D O I：

10.1101/cshperspect.a015164

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

100103 [病原生物学]; 100218 [急诊医学];

摘要：

The discovery of methods for reprogramming adult somatic cells into induced pluripotent stem cells (iPSCs) has raised the possibility of producing truly personalized treatment options for numerous diseases. Similar to embryonic stem cells (ESCs), iPSCs can give rise to any cell type in the body and are amenable to genetic correction by homologous recombination. These ESC properties of iPSCs allow for the development of permanent corrective therapies for many currently incurable disorders, including inherited skin diseases, without using embryonic tissues or oocytes. Here, we review recent progress and limitations of iPSC research with a focus on clinical applications of iPSCs and using iPSCs to model human diseases for drug discovery in the field of dermatology.

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页数：15

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