Serum levels of 25-hydroxyvitamin D in mothers of Swedish and of Somali origin who have children with and without autism

被引:67
作者
Fernell, Elisabeth [1 ,2 ,3 ,6 ]
Barnevik-Olsson, Martina [4 ]
Bagenholm, Gunnel [5 ]
Gillberg, Christopher [6 ]
Gustafsson, Sven [7 ]
Saaf, Maria [8 ]
机构
[1] Autism Ctr Young Children Handicap & Habilitat, Stockholm, Sweden
[2] Skaraborg Hosp, Dept Paediat, Unit Dev Disorders, S-54185 Skovde, Sweden
[3] Skaraborg Hosp, FoU Ctr, S-54185 Skovde, Sweden
[4] PRIMA Child & Adolescent Psychiat, Stockholm, Sweden
[5] Karolinska Univ Hosp, Astrid Lindgren Childrens Hosp, Dept Paediat, Stockholm, Sweden
[6] Univ Gothenburg, Sahlgrenska Acad, Inst Neurosci & Physiol Child & Adolescent Psychi, Gothenburg, Sweden
[7] Karolinska Inst, Dept Mol Med & Surg, Stockholm, Sweden
[8] Karolinska Univ Hosp, Dept Endocrinol, Stockholm, Sweden
关键词
Autism; 25-hydroxyvitamin D; Somali population; VITAMIN-D DEFICIENCY; PROTEIN EXPRESSION; RAT; SCHIZOPHRENIA; IMMIGRANTS; SWEDEN; BORN;
D O I
10.1111/j.1651-2227.2010.01755.x
中图分类号
R72 [儿科学];
学科分类号
100202 ;
摘要
Aim: To analyse serum levels of 25-hydroxyvitamin D in mothers of Somali origin and those of Swedish origin who have children with and without autism as there is a growing evidence that low vitamin D impacts adversely on brain development. Method: Four groups of mothers were invited to participate; 20 with Somali origin with at least one child with autism, 20 with Somali origin without a child with autism, 20 of Swedish origin with at least one child with autism and 20 with Swedish origin without a child with autism. Two blood samples were collected from each individual; during autumn and spring. Results: Between 12 and 17 mothers from the different groups accepted to participate, both groups of mothers of Somali origin had significantly lower values of 25-hydroxyvitamin D compared with Swedish mothers. The difference of 25-hydroxyvitamin D between mothers of Somali origin with and without a child with autism was not significant. Conclusion: Our findings of low vitamin D levels in Somali women entail considerable consequences in a public health perspective. The observed tendency, i.e. the lowest values in mothers of Somali origin with a child with autism was in the predicted direction, supporting the need for further research of vitamin D levels in larger samples of Somali mothers of children with and without autism.
引用
收藏
页码:743 / 747
页数:5
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