Apelin signalling: a promising pathway from cloning to pharmacology

被引：144

作者：

Masri, B ^{[1
]}

Knibiehler, B ^{[1
]}

Audigier, Y ^{[1
]}

机构：

[1] CHU Rangueil, TSA 50032, INSERM, U 589, F-31059 Toulouse 9, France

来源：

CELLULAR SIGNALLING | 2005年 / 17卷 / 04期

关键词：

G-protein-coupled receptors; apelin; signal transduction; cardiovascular system; central nervous system; HIV infection;

D O I：

10.1016/j.cellsig.2004.09.018

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

The discovery of new signalling pathways is always followed by the development of pharmacological agents as drugs that can be used in the treatment of diseases resulting from a dysfunction of the signalling pathway in question. Apelin signalling plays a role in the central and peripheral regulation of the cardiovascular system, in water and food intake, and possibly in immune function. Up-regulation of ligand and receptor is also associated with pathophysiological states such as cardiac dysfunction and neovascularisation. Finally, the apelin receptor is a coreceptor for the entry of several HIV-1 and SIV strains. In view of these features, the apelin receptor constitutes a very interesting target for the design of new drugs for treating the prime causes of human mortality. (C) 2004 Elsevier Inc. All rights reserved.

引用

页码：415 / 426

页数：12

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