Y chromosome sequence variation and the history of human populations

被引：685

作者：

Underhill, PA ^{[1
]}

Shen, PD

Lin, AA

Jin, L

Passarino, G

Yang, WH

Kauffman, E

Bonné-Tamir, B

Bertranpetit, J

Francalacci, P

Ibrahim, M

Jenkins, T

Kidd, JR

Mehdi, SQ

Seielstad, MT

Wells, RS

Piazza, A

Davis, RW

Feldman, MW

Cavalli-Sforza, LL

Oefner, PJ

机构：

[1] Stanford Univ, Dept Genet, Stanford, CA 94305 USA

[2] Stanford DNA Sequencing & Technol Ctr, Palo Alto, CA USA

[3] Univ Texas, Ctr Human Genet, Houston, TX USA

[4] Tel Aviv Univ, Sackler Fac Med, IL-69978 Tel Aviv, Israel

[5] Univ Pompeu Fabra, Fac Ciencies Salut Vida, Unitat Biol Evolut, Barcelona, Spain

[6] Univ Sassari, Dipartimento Zool & Antropol Biol, I-07100 Sassari, Italy

[7] Univ Khartoum, Inst Endem Dis, Khartoum, Sudan

[8] S African Inst Med Res, Sch Pathol, Dept Human Genet, Johannesburg, South Africa

[9] Univ Witwatersrand, Johannesburg, South Africa

[10] Yale Univ, Sch Med, Dept Genet, New Haven, CT 06510 USA

[11] Biomed & Genet Engn Labs, Dr AQ Khan Res Labs, Islamabad, Pakistan

[12] Harvard Univ, Sch Publ Hlth, Program Populat Genet, Boston, MA 02115 USA

[13] Univ Oxford, Wellcome Trust Ctr Human Genet, Oxford OX1 2JD, England

[14] Univ Turin, Dept Genet, Dept Genet Biol & Biochem, Turin, Italy

[15] Stanford Univ, Dept Biol Sci, Herrin Labs, Stanford, CA 94305 USA

来源：

NATURE GENETICS | 2000年 / 26卷 / 03期

基金：

美国国家卫生研究院;

关键词：

D O I：

10.1038/81685

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

Binary polymorphisms associated with the non-recombining region of the human Y chromosome (NRY) preserve the paternal genetic: legacy of our species that has persisted to the present, permitting inference of human evolution, population affinity and demographic history(1). We used denaturing highperformance liquid chromatography (DHPLC; ref. 2) to identify 160 of the 166 bi-allelic and 1 tri-allelic site that formed a parsimonious; genealogy of 116 haplotypes, several of which display distinct population affinities based on the analysis of 1062 globally representative individuals. A minority of contemporary East Africans and Khoisan represent the descendants of the most ancestral patrilineages of anatomically modern humans that left Africa between 35,000 and 89,000 years ago.

引用

页码：358 / 361

页数：4

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