Y chromosome sequence variation and the history of human populations

被引:685
作者
Underhill, PA [1 ]
Shen, PD
Lin, AA
Jin, L
Passarino, G
Yang, WH
Kauffman, E
Bonné-Tamir, B
Bertranpetit, J
Francalacci, P
Ibrahim, M
Jenkins, T
Kidd, JR
Mehdi, SQ
Seielstad, MT
Wells, RS
Piazza, A
Davis, RW
Feldman, MW
Cavalli-Sforza, LL
Oefner, PJ
机构
[1] Stanford Univ, Dept Genet, Stanford, CA 94305 USA
[2] Stanford DNA Sequencing & Technol Ctr, Palo Alto, CA USA
[3] Univ Texas, Ctr Human Genet, Houston, TX USA
[4] Tel Aviv Univ, Sackler Fac Med, IL-69978 Tel Aviv, Israel
[5] Univ Pompeu Fabra, Fac Ciencies Salut Vida, Unitat Biol Evolut, Barcelona, Spain
[6] Univ Sassari, Dipartimento Zool & Antropol Biol, I-07100 Sassari, Italy
[7] Univ Khartoum, Inst Endem Dis, Khartoum, Sudan
[8] S African Inst Med Res, Sch Pathol, Dept Human Genet, Johannesburg, South Africa
[9] Univ Witwatersrand, Johannesburg, South Africa
[10] Yale Univ, Sch Med, Dept Genet, New Haven, CT 06510 USA
[11] Biomed & Genet Engn Labs, Dr AQ Khan Res Labs, Islamabad, Pakistan
[12] Harvard Univ, Sch Publ Hlth, Program Populat Genet, Boston, MA 02115 USA
[13] Univ Oxford, Wellcome Trust Ctr Human Genet, Oxford OX1 2JD, England
[14] Univ Turin, Dept Genet, Dept Genet Biol & Biochem, Turin, Italy
[15] Stanford Univ, Dept Biol Sci, Herrin Labs, Stanford, CA 94305 USA
基金
美国国家卫生研究院;
关键词
D O I
10.1038/81685
中图分类号
Q3 [遗传学];
学科分类号
071007 ; 090102 ;
摘要
Binary polymorphisms associated with the non-recombining region of the human Y chromosome (NRY) preserve the paternal genetic: legacy of our species that has persisted to the present, permitting inference of human evolution, population affinity and demographic history(1). We used denaturing highperformance liquid chromatography (DHPLC; ref. 2) to identify 160 of the 166 bi-allelic and 1 tri-allelic site that formed a parsimonious; genealogy of 116 haplotypes, several of which display distinct population affinities based on the analysis of 1062 globally representative individuals. A minority of contemporary East Africans and Khoisan represent the descendants of the most ancestral patrilineages of anatomically modern humans that left Africa between 35,000 and 89,000 years ago.
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页码:358 / 361
页数:4
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