Use of infrared attenuated total reflectance spectroscopy for the in vivo measurement of hydration level and silicone distribution in the stratum corneum following shin coverage by polymeric dressings

被引：21

作者：

Branagan, M ^{[1
]}

Chenery, DH ^{[1
]}

Nicholson, S ^{[1
]}

机构：

[1] Smith & Nephew Res Ctr, York YO10 5DF, N Yorkshire, England

来源：

SKIN PHARMACOLOGY AND APPLIED SKIN PHYSIOLOGY | 2000年 / 13卷 / 3-4期

关键词：

skin hydration; silicone distribution; infrared spectroscopy;

D O I：

10.1159/000029921

中图分类号：

R75 [皮肤病学与性病学];

学科分类号：

100206 ;

摘要：

The ability of wound dressings to hydrate the stratum corneum has been tested experimentally using attenuated total reflectance (ATR) infrared spectroscopy. A silicone gel dressing was able to hydrate the stratum corneum to the extent that its water content within the sampled volume was >60% after 5 h of contact compared with about 15% of normal exposed skin and about 30% for a highly permeable hydrophilic polyurethane dressing. An ATR method was devised to determine the presence and depth of penetration of silicone in the stratum corneum as a result of skin coverage by the polymeric dressing. Copyright (C) 2000 S. Karger AG. Basel.

引用

页码：157 / 164

页数：8

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