The first woman to give birth to two children following transplantation of frozen/thawed ovarian tissue

被引：132

作者：

Ernst, Erik ^{[2
]}

Bergholdt, Stinne ^{[3
]}

Jorgensen, Jan Stener ^{[4
]}

Andersen, Claus Yding ^{[1
]}

机构：

[1] Univ Copenhagen Hosp, Reprod Biol Lab, Juliane Marie Ctr Women Children & Reprod, DK-2100 Copenhagen, Denmark

[2] Aarhus Univ Hosp, Dept Gynecol & Obstet, DK-8000 Aarhus, Denmark

[3] Univ So Denmark, Res Unit Gen Practice, Odense, Denmark

[4] Odense Univ Hosp, Dept Gynecol & Obstet, DK-5000 Odense, Denmark

来源：

HUMAN REPRODUCTION | 2010年 / 25卷 / 05期

关键词：

ovarian transplantation; ovarian cryopreservation; natural conception; FERTILITY PRESERVATION; AUTOTRANSPLANTATION; CRYOPRESERVATION; FAILURE; PATIENT;

D O I：

10.1093/humrep/deq033

中图分类号：

R71 [妇产科学];

学科分类号：

100211 ;

摘要：

Worldwide eight children have been born as a result of transplanting frozen/thawed ovarian tissue. Two of these children were born in Denmark following transport of the ovarian tissue for a period of 5 h prior to cryopreservation. One of these women, who was originally transplanted with six pieces of ovarian cortex, after having experienced a period of menopause has now conceived again following natural conception. She gave birth to a healthy girl on 23 September 2008 and is therefore the first woman in the world to have had two children, from separate pregnancies, born as a result of transplanting frozen/thawed ovarian tissue. This result encourages further development of cryopreservation of ovarian tissue for fertility preservation as a clinical procedure for girls and young women facing gonadotoxic treatment.

引用

页码：1280 / 1281

页数：2

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