Colon cancer

被引：424

作者：

Labianca, Roberto ^{[1
]}

Beretta, Giordano D. ^{[2
]}

Kildani, Basem ^{[2
]}

Milesi, Laura ^{[1
]}

Merlin, Federica ^{[2
]}

Mosconi, Stefania ^{[1
]}

Pessi, M. Adelaide ^{[1
]}

Prochilo, Tiziana ^{[2
]}

Quadri, Antonello ^{[1
]}

Gatta, Gemma ^{[3
]}

de Braud, Filippo ^{[5
,6
]}

Wils, Jacques ^{[4
]}

机构：

[1] Osped Riuniti Bergamo, I-24128 Bergamo, Italy

[2] Osped St Orsola Fatebenefratelli, Med Oncol Unit, Brescia, Italy

[3] Ist Nazl Tumori, Fdn IRCCS, Epidemiol Unit, I-20133 Milan, Italy

[4] Laurentius Hosp, Dept Med Oncol, Roermond, Netherlands

[5] START Project, Milan, Italy

[6] European Inst Oncol, Clin Pharmacol & New Drugs Dev Unit, Milan, Italy

来源：

CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY | 2010年 / 74卷 / 02期

关键词：

Colon cancer; Strategy; Treatment; METASTATIC COLORECTAL-CANCER; GROWTH-FACTOR RECEPTOR; HEPATIC ARTERIAL INFUSION; PHASE-III TRIAL; PERIOPERATIVE BLOOD-TRANSFUSIONS; MULTICENTER RANDOMIZED-TRIAL; FACTORS INFLUENCING SURVIVAL; HIGH-DOSE LEUCOVORIN; PLUS FOLINIC ACID; QUALITY-OF-LIFE;

D O I：

10.1016/j.critrevonc.2010.01.010

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 [肿瘤学];

摘要：

Colon cancer is one of the leading tumours in the world and it is considered among the big killers, together with lung, prostate and breast cancer. In the recent years very important advances occurred in the field of treatment of this frequent disease: adjuvant chemotherapy was demonstrated to be effective, chiefly in stage III patients, and surgery was optimized in order to achieve the best results with a low morbidity. Several new target-oriented drugs are under evaluation and some of them (cetuximab and bevacizumab) have already exhibited a good activity/efficacy, mainly in combination with chemotherapy. The development of updated recommendations for the best management of these patients is crucial in order to obtain the best results, not only in clinical research but also in every-day practice. This report summarizes the most important achievements in this field and provides the readers useful suggestions for their professional practice. (C) 2010 Elsevier Ireland Ltd. All rights reserved.

引用

页码：106 / 132

页数：27

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