Dendritic Cell-Derived Exosomes for Cancer Immunotherapy: What's Next?

被引：269

作者：

Viaud, Sophie ^{[2
]}

Thery, Clotilde ^{[3
,4
]}

Ploix, Stephanie

Tursz, Thomas ^{[2
]}

Lapierre, Valerie

Lantz, Olivier ^{[3
,4
]}

Zitvogel, Laurence ^{[2
,5
]}

Chaput, Nathalie ^{[1
,2
]}

机构：

[1] Inst Gustave Roussy, Ctr Invest Clin Biotherapie 507, Lab Therapie Cellulaire, F-94805 Villejuif, France

[2] INSERM, U805, Villejuif, France

[3] Inst Curie, F-75231 Paris, France

[4] INSERM, U932, Paris, France

[5] Univ Paris 11, Fac Med, Le Kremlin Bicetre, France

来源：

CANCER RESEARCH | 2010年 / 70卷 / 04期

关键词：

PEPTIDE-BASED VACCINE; T-CELLS; TRANSFERRIN RECEPTOR; MEMBRANE-VESICLES; NKG2D LIGANDS; DOWN-MODULATE; INDUCE; ACCUMULATION; ACTIVATION; COMPLEXES;

D O I：

10.1158/0008-5472.CAN-09-3276

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Exosomes are nanovesicles originating from late endosomal compartments and secreted by most living cells in ex vivo cell culture conditions. The interest in exosomes was rekindled when B-cell and dendritic cell-derived exosomes were shown to mediate MHC-dependent immune responses. Despite limited understanding of exosome biogenesis and physiological relevance, accumulating evidence points to their bioactivity culminating in clinical applications in cancer. This review focuses on the preclinical studies exploiting the immunogenicity of dendritic cell-derived exosomes (Dex) and will elaborate on the past and future vaccination trials conducted using Dex strategy in melanoma and non-small cell lung cancer patients. Cancer Res; 70(4); 1281-5. (C) 2010 AACR.

引用

页码：1281 / 1285

页数：5

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