Novel observation of a circular dichroism band originating from amyloid fibril

被引：5

作者：

Abe, H

Nakanishi, H

机构：

[1] Natl Inst Adv Ind Sci & Technol, Biol Informat Res Ctr, Tsukuba, Ibaraki 3058566, Japan

[2] Sci Univ Tokyo, Dept Biol Sci & Technol, Noda, Chiba 2780022, Japan

来源：

ANALYTICAL SCIENCES | 2003年 / 19卷 / 01期

关键词：

D O I：

10.2116/analsci.19.171

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

A peptide fragment of a non-amyloid-beta component (NAC(1-13)) was studied by CD and electron microscopy. Typical amyloid fibrils were observed by EM in a solution of NAC(1-13). In addition to the beta-structural CD band in the far-UV region, a novel CD band near 285 nm was observed in a peptide solution of NAC(1-13). Taking the NAC(1-13) to contain neither an aromatic amino acid residue nor cystine into account, the CD band can be attributed to amyloid fibrils of NAC(1-13).

引用

页码：171 / 173

页数：3

共 11 条

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