Effect of the nitric oxide level in the medial preoptic area on male copulatory behavior in rats

被引:65
作者
Sato, Y [1 ]
Horita, H [1 ]
Kurohata, T [1 ]
Adachi, H [1 ]
Tsukamoto, T [1 ]
机构
[1] Sapporo Med Univ, Sch Med, Dept Urol, Sapporo, Hokkaido 060, Japan
关键词
mount; nitrite; nitrate; microdialysis; L-arginine;
D O I
10.1152/ajpregu.1998.274.1.R243
中图分类号
Q4 [生理学];
学科分类号
071003 ;
摘要
We investigated the influence of the extracellular nitric oxide (NO) level on male copulatory behavior. We confirmed the changes of nitrite (NO2-) and nitrate (NO3-) in the medial preoptic area (MPOA) by administration of the NO precursor L-arginine (L-Arg, 10 mM) or the NO synthase inhibitor N-G-monomethyl-L-arginine (L-NMMA, 10 mM) via a dialysis probe. NO2- and NO3- were measured simultaneously by an in vivo microdialysis method coupled with the Griess reaction. L-Arg induced significant elevations of extracellular NO2- and NO3-. L-NMMA significantly reduced NO2- and NO3- levels. We observed male copulatory behavior during infusion of L-Arg or L-NMMA. The mount rate of male rats significantly increased during infusion of L-Arg in the MPOA. Administration of L-NMMA reduced the mount rate. These findings suggested that the elevation of extracellular NO in the MPOA facilitates male copulatory behavior of rats, whereas the decrease of NO reduces their copulatory behavior.
引用
收藏
页码:R243 / R247
页数:5
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