NHEJ and its backup pathways in chromosomal translocations

被引:72
作者
Lieber, Michael R. [1 ]
机构
[1] Univ So Calif, Norris Canc Ctr, Los Angeles, CA 90089 USA
关键词
DNA ENDS; LIGASE-IV; MECHANISM; MRE11; RECOMBINATION; POLYMERASES; ROLES; CELLS;
D O I
10.1038/nsmb0410-393
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Two recent papers break major new ground on the issues of NHEJ, backup pathways for NHEJ and how these relate to the chromosomal translocation process.
引用
收藏
页码:393 / 395
页数:4
相关论文
共 24 条
[1]   The pathways and outcomes of mycobacterial NHEJ depend on the structure of the broken DNA ends [J].
Aniukwu, Jideofor ;
Glickman, Michael S. ;
Shuman, Stewart .
GENES & DEVELOPMENT, 2008, 22 (04) :512-527
[2]   Human DNA polymerases λ and β show different efficiencies of translesion DNA synthesis past abasic sites and alternative mechanisms for frameshift generation [J].
Blanca, G ;
Villani, G ;
Shevelev, I ;
Ramadan, K ;
Spadari, S ;
Hübscher, U ;
Maga, G .
BIOCHEMISTRY, 2004, 43 (36) :11605-11615
[3]   Alternative end-joining catalyzes robust IgH locus deletions and translocations in the combined absence of ligase 4 and Ku70 [J].
Boboila, Cristian ;
Jankovic, Mila ;
Yan, Catherine T. ;
Wang, Jing H. ;
Wesemann, Duane R. ;
Zhang, Tingting ;
Fazeli, Alex ;
Feldman, Lauren ;
Nussenzweig, Andre ;
Nussenzweig, Michel ;
Alt, Frederick W. .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2010, 107 (07) :3034-3039
[4]   Interactions of the DNA ligase IV-XRCC4 complex with DNA ends and the DNA-dependent protein kinase [J].
Chen, L ;
Trujillo, K ;
Sung, P ;
Tomkinson, AE .
JOURNAL OF BIOLOGICAL CHEMISTRY, 2000, 275 (34) :26196-26205
[5]   Rag mutations reveal robust alternative end joining [J].
Corneo, Barbara ;
Wendland, Rebecca L. ;
Deriano, Ludovic ;
Cui, Xiaoping ;
Klein, Isaac A. ;
Wong, Serre-Yu ;
Arnal, Suzzette ;
Holub, Abigail J. ;
Weller, Geoffrey R. ;
Pancake, Bette A. ;
Shah, Sundeep ;
Brandt, Vicky L. ;
Meek, Katheryn ;
Roth, David B. .
NATURE, 2007, 449 (7161) :483-U10
[6]   Roles for NBS1 in Alternative Nonhomologous End-Joining of V(D)J Recombination Intermediates [J].
Deriano, Ludovic ;
Stracker, Travis H. ;
Baker, Annalee ;
Petrini, John H. J. ;
Roth, David B. .
MOLECULAR CELL, 2009, 34 (01) :13-25
[7]   Multiple functions of MRN in end-joining pathways during isotype class switching [J].
Dinkelmann, Maria ;
Spehalski, Elizabeth ;
Stoneham, Trina ;
Buis, Jeffrey ;
Wu, Yipin ;
Sekiguchi, JoAnn M. ;
Ferguson, David O. .
NATURE STRUCTURAL & MOLECULAR BIOLOGY, 2009, 16 (08) :808-U25
[8]   Mechanistic flexibility as a conserved theme across 3 billion years of nonhomologous DNA end-joining [J].
Gu, Jiafeng ;
Lieber, Michael R. .
GENES & DEVELOPMENT, 2008, 22 (04) :411-415
[9]   XRCC4:DNA ligase IV can ligate incompatible DNA ends and can ligate across gaps [J].
Gu, Jiafeng ;
Lu, Haihui ;
Tippin, Brigette ;
Shimazaki, Noriko ;
Goodman, Myron F. ;
Lieber, Michael R. .
EMBO JOURNAL, 2007, 26 (04) :1010-1023
[10]   Altered kinetics of nonhomologous end joining and class switch recombination in ligase IV-deficient B cells [J].
Han, Li ;
Yu, Kefei .
JOURNAL OF EXPERIMENTAL MEDICINE, 2008, 205 (12) :2745-2753