Hyperosmolar nonketotic coma precipitated by lithium-induced nephrogenic diabetes insipidus

被引：7

作者：

Azam, H ^{[1
]}

Newton, RW ^{[1
]}

Morris, AD ^{[1
]}

Thompson, CJ ^{[1
]}

机构：

[1] Univ Dundee, Ninewells Hosp & Med Sch, Dept Diabet, Dundee DD1 9SY, Scotland

来源：

POSTGRADUATE MEDICAL JOURNAL | 1998年 / 74卷 / 867期

关键词：

hyperosmolar coma; lithium; diabetes insipidus;

D O I：

10.1136/pgmj.74.867.39

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

A 45-year-old man, with a 10-year history of manic depression treated with lithium, was admitted with hyperosmolar, nonketotic coma. He gave a five-year history of polyuria and polydipsia, during which time urinalysis had been negative for glucose. After recovery from hyperglycaemia, he remained polyuric despite normal blood glucose concentrations; water deprivation testing indicated nephrogenic diabetes insipidus, likely to be lithium-induced. We hypothesize that when this man developed type 2 diabetes, chronic polyuria due to nephrogenic diabetes insipidus was sufficient to precipitate hyperosmolar dehydration.

引用

页码：39 / 41

页数：3

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