The ubiquitin-proteasome pathway in cancer

被引：191

作者：

Spataro, V ^{[1
]}

Norbury, C ^{[1
]}

Harris, AL ^{[1
]}

机构：

[1] Univ Oxford, Inst Mol Med, Imperial Canc Res Fund, Mol Oncol Lab, Oxford OX3 9DS, England

来源：

BRITISH JOURNAL OF CANCER | 1998年 / 77卷 / 03期

关键词：

ubiquitin; proteasome; oncogenesis; drug resistance; immune escape;

D O I：

10.1038/bjc.1998.71

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Degradation by the 26S proteasome of specific proteins that have been targeted by the ubiquitin pathway is the major intracellular non-lysosomal proteolytic mechanism and is involved in a broad range of processes, such as cell cycle progression, antigen presentation and control of gene expression. Recent work, reviewed here, has shown that this pathway is often the target of cancer-related deregulation and can underlie processes, such as oncogenic transformation, tumour progression, escape from immune surveillance and drug resistance.

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页码：448 / 455

页数：8

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