学术探索
学术期刊
新闻热点
数据分析
智能评审

Identification of a novel human papillomavirus (HPV97) related to HPV18 and HPV45

被引：9
作者：
Chen, Zigui
Fu, Leiping
Herrero, Rolando
Schiffman, Mark
Burk, Robert D.
机构：
[1] Albert Einstein Coll Med, Dept Microbiol & Immunol, Bronx, NY 10461 USA
[2] Costa Rican Fdn Hlth Sci, Proyecto Epidemiol Guanacaste, San Jose, Costa Rica
[3] US Dept Hlth & Human Serv, Div Canc Epidemiol & Genet, NCI, NIH, Bethesda, MD USA
[4] Albert Einstein Coll Med, Dept Pediat, Bronx, NY 10467 USA
[5] Albert Einstein Coll Med, Dept Epidemiol & Populat Hlth, Bronx, NY 10467 USA
[6] Albert Einstein Coll Med, Dept Obstet Gynecol & Womans Hlth, Bronx, NY 10467 USA
[7] Albert Einstein Coll Med, Albert Einstein Canc Ctr, Bronx, NY 10467 USA
来源：
INTERNATIONAL JOURNAL OF CANCER | 2007年 / 121卷 / 01期
关键词：
human papillomavirus; novel type; phylogeny; evolution;
D O I：
10.1002/ijc.22632
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Human papillomavirus (HPV) type 97 was identified and the genome was cloned from cervicovaginal cells of a Costa Rican woman with a normal Pap smear. The HPV97 L1 open reading frame (ORF) was most closely related to HPV45 (84% identity) and HPV18 (79% identity), placing it into the high-risk alpha 7 species. Ectopic expression of the HPV97 E6 and E7 proteins significantly decreased steady state p53 and pRb levels using an in vitro cotransfection assay, respectively. These data suggest that HPV97 shares a most recent common ancestor with HPV18 and HPV45 and should be evaluated in cancer specimens from different geographic populations. (C) 2007 Wiley-Liss, Inc.
引用
收藏
页码：193 / 198
页数：6
相关论文
共 39 条
[1]   NUCLEAR FACTOR-I AND EPITHELIAL CELL-SPECIFIC TRANSCRIPTION OF HUMAN PAPILLOMAVIRUS TYPE-16 [J].
APT, D ;
CHONG, T ;
LIU, YC ;
BERNARD, HU .
JOURNAL OF VIROLOGY, 1993, 67 (08) :4455-4463
[2]   Genome variation of human papillomavirus types: Phylogenetic and medical implications [J].
Bernard, HU ;
Calleja-Macias, IE ;
Dunn, ST .
INTERNATIONAL JOURNAL OF CANCER, 2006, 118 (05) :1071-1076
[3]   Comparisons of HPV DNA detection by MY09/11 PCR methods [J].
Castle, PE ;
Schiffman, M ;
Gravitt, PE ;
Kendall, H ;
Fishman, S ;
Dong, H ;
Hildesheim, A ;
Herrero, R ;
Bratti, MC ;
Sherman, ME ;
Lorincz, A ;
Schussler, JE ;
Burk, RD .
JOURNAL OF MEDICAL VIROLOGY, 2002, 68 (03) :417-423
[4]   TRANSCRIPTION OF THE TRANSFORMING GENES OF THE ONCOGENIC HUMAN PAPILLOMAVIRUS-16 IS STIMULATED BY TUMOR PROMOTORS THROUGH AP1 BINDING-SITES [J].
CHAN, WK ;
CHONG, T ;
BERNARD, HU ;
KLOCK, G .
NUCLEIC ACIDS RESEARCH, 1990, 18 (04) :763-769
[5]   Human papillomavirus types in invasive cervical cancer worldwide:: a meta-analysis [J].
Clifford, GM ;
Smith, JS ;
Plummer, M ;
Muñoz, N ;
Franceschi, S .
BRITISH JOURNAL OF CANCER, 2003, 88 (01) :63-73
[6]   Classification of papillomaviruses [J].
de Villiers, EM ;
Fauquet, C ;
Broker, TR ;
Bernard, HU ;
zur Hausen, H .
VIROLOGY, 2004, 324 (01) :17-27
[7]   GROWTH ARREST BY INDUCTION OF P53 IN DNA DAMAGED KERATINOCYTES IS BYPASSED BY HUMAN PAPILLOMAVIRUS-16 E7 [J].
DEMERS, GW ;
FOSTER, SA ;
HALBERT, CL ;
GALLOWAY, DA .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1994, 91 (10) :4382-4386
[8]   PREVALENCE OF DELETIONS OF YY1-BINDING SITES IN EPISOMAL HPV-16 DNA FROM CERVICAL CANCERS [J].
DONG, XP ;
STUBENRAUCH, F ;
BEYERFINKLER, E ;
PFISTER, H .
INTERNATIONAL JOURNAL OF CANCER, 1994, 58 (06) :803-808
[9]   MOLECULAR ANALYSIS OF INTEGRATED HUMAN PAPILLOMAVIRUS-16 SEQUENCES IN THE CERVICAL-CANCER CELL-LINE SIHA [J].
ELAWADY, MK ;
KAPLAN, JB ;
OBRIEN, SJ ;
BURK, RD .
VIROLOGY, 1987, 159 (02) :389-398
[10]   THE E6/E7 PROMOTER OF HUMAN PAPILLOMAVIRUS TYPE-16 IS ACTIVATED IN THE ABSENCE OF E2 PROTEINS BY A SEQUENCE-ABERRANT SP1 DISTAL ELEMENT [J].
GLOSS, B ;
BERNARD, HU .
JOURNAL OF VIROLOGY, 1990, 64 (11) :5577-5584
1234