Deoxyribozyme-catalyzed labeling of RNA

被引：61

作者：

Baum, Dana A. ^{[1
]}

Silverman, Scott K. ^{[1
]}

机构：

[1] Univ Illinois, Dept Chem, Urbana, IL 61801 USA

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2007年 / 46卷 / 19期

关键词：

deoxyribozymes; fluorescent probes; FRET (fluorescence resonant energy transfer); macromolecular folding; RNA structures;

D O I：

10.1002/anie.200700357

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Tag team: A deoxyribozyme is used in a general strategy for site-specific covalent modification of RNA. This strategy was used to append the fluorescence resonant energy transfer (FRET) pair, fluorescein and tetramethylrhodamine (tamra), to the 160-nucleotide P4-P6 RNA, thereby enabling a FRET experiment to be performed for this RNA. (Graph Presented). © 2007 Wiley-VCH Verlag GmbH & Co. KGaA.

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页码：3502 / 3504

页数：3

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