Calcimimetics - fooling the calcium receptor

被引：7

作者：

Ritz, E ^{[1
]}

机构：

[1] Heidelberg Univ, Dept Internal Med, Div Nephrol, D-69115 Heidelberg, Germany

来源：

PEDIATRIC NEPHROLOGY | 2005年 / 20卷 / 01期

关键词：

calcimimetics; renal hyperparathyroidism; chronic renal failure; calcium-sensing receptor;

D O I：

10.1007/s00467-004-1671-1

中图分类号：

R72 [儿科学];

学科分类号：

100202 ;

摘要：

The cloning and characterization of a calcium-sensing receptor from bovine parathyroid cells has opened up the possibility of modulating the activity of this receptor protein by organic small molecules, either increasing the sensitivity for calcium (calcimimetics) or decreasing the sensitivity (calciolytics), thus suppressing or stimulating parathyroid hormone (PTH) secretion and synthesis, respectively. In primary and secondary hyperparathyroidism, calcimimetics have proven to effectively lower the PTH concentration with minimal side effects. In secondary hyperparathyroidism, a specific advantage is the concomitant lowering of serum calcium and phosphate concentrations.

引用

页码：15 / 18

页数：4

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