2,4,5-trisubstituted imidazoles: Novel nontoxic modulators of P-glycoprotein mediated multidrug resistance. Part 1

被引：43

作者：

Sarshar, S ^{[1
]}

Zhang, CZ ^{[1
]}

Moran, EJ ^{[1
]}

Krane, S ^{[1
]}

Rodarte, JC ^{[1
]}

Benbatoul, KD ^{[1
]}

Dixon, R ^{[1
]}

Mjalli, AMM ^{[1
]}

机构：

[1] Ontogen Corp, Carlsbad, CA 92009 USA

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2000年 / 10卷 / 23期

关键词：

D O I：

10.1016/S0960-894X(00)00520-5

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

N-4,5-Di-(4-dialkylamino)phenyl imidazoles (A) are potent modulators of P-glycoprotein mediated multidrug resistance. This manuscript describes the discovery and lead optimization of this novel class of inhibitors. (C) 2000 Elsevier Science Ltd. All rights reserved.

引用

页码：2599 / 2601

页数：3

共 14 条

[1] Biochemical, cellular, and pharmacological aspects of the multidrug transporter
Ambudkar, SV
Dey, S
Hrycyna, CA
Ramachandra, M
Pastan, I
Gottesman, MM
[J]. ANNUAL REVIEW OF PHARMACOLOGY AND TOXICOLOGY, 1999, 39 : 361 - 398
[2] BRADLEY G, 1989, CANCER RES, V49, P2790
[3] P-GLYCOPROTEIN - MULTIDRUG-RESISTANCE AND A SUPERFAMILY OF MEMBRANE-ASSOCIATED TRANSPORT PROTEINS
JURANKA, PF
ZASTAWNY, RL
LING, V
[J]. FASEB JOURNAL, 1989, 3 (14) : 2583 - 2592
[4] KRISHNAMACHARY N, 1993, CANCER RES, V53, P3658
[5] Majalli A.M.M., 1997, US Patent, Patent No. [5700826, 5,700,826]
[6] Mjalli A. M. M, 1998, Imidazole Dervativesas Mdr Modulators, Patent No. [US 5840721, 5840721]
[7] MJALLI AMM, 1998, Patent No. 5756527
[8] Newman MJ, 2000, CANCER RES, V60, P2964
[9] RADERER M, 1993, CANCER, V72, P3553, DOI 10.1002/1097-0142(19931215)72:12<3553::AID-CNCR2820721203>3.0.CO
[10] 2-B

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