Synthesis of tetrasubstituted imidazoles via alpha-(N-acyl-N-alkylamino)-beta-ketoamides on Wang resin

被引：147

作者：

Zhang, CZ ^{[1
]}

Moran, EJ ^{[1
]}

Woiwode, TF ^{[1
]}

Short, KM ^{[1
]}

Mjalli, AMM ^{[1
]}

机构：

[1] ONTOGEN CORP,CARLSBAD,CA 92009

来源：

TETRAHEDRON LETTERS | 1996年 / 37卷 / 06期

关键词：

D O I：

10.1016/0040-4039(95)02310-0

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The first example of a four component condensation of arylglyoxals, 1 degrees amines, carboxylic acids and isocyanides on Wang resin is described. These products can be cyclized in the presence of NH4OAc-AcOH to yield tetrasubstituted imidazoles.

引用

页码：751 / 754

页数：4

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