Birth cohort effect on prevalence of age-related maculopathy in the Beaver Dam Eye Study

被引:16
作者
Huang, GH
Klein, R
Klein, BEK
Tomany, SC
机构
[1] Univ Wisconsin, Dept Populat Hlth Sci, Sch Med, Madison, WI 53726 USA
[2] Univ Wisconsin, Sch Med, Dept Biostat & Med Informat, Madison, WI USA
[3] Univ Wisconsin, Sch Med, Dept Ophthalmol & Vis Sci, Madison, WI USA
关键词
cohort effect; cohort studies; generalized estimating equation; macular degeneration; risk adjustment;
D O I
10.1093/aje/kwg011
中图分类号
R1 [预防医学、卫生学];
学科分类号
1004 ; 120402 ;
摘要
The number of people in the United States with age-related maculopathy is increasing in recent years because of increasing longevity. However, it is possible that a birth cohort effect, due to different levels of exposure to risk factors, may explain changes in the prevalence of age-related maculopathy by age. In this report, the authors utilize data from the population-based Beaver Dam Eye Study (1988-2000) to examine this possibility. They propose a strategy to handle issues of longitudinal measurements and risk factor adjustment for analyzing the birth cohort effect. Results from the analysis (after adjusting for known risk factors) showed an apparent independent birth cohort effect on age-related maculopathy. The authors also found a strong positive association between age-related maculopathy and age, when comparing participants from the same birth cohort. The birth cohort effect was the same across different age groups, except for early age-related maculopathy, where older age increased the association. Our findings demonstrate that the birth cohort effect is likely attributable to unmeasured risk factors for age-related maculopathy and limitations of risk factor measurements. Further study of possible unmeasured risk factors that cause the cohort effect may help us understand the etiology of the disease.
引用
收藏
页码:721 / 729
页数:9
相关论文
共 26 条
[1]  
ALLAIN CC, 1974, CLIN CHEM, V20, P470
[2]   INDIRECT STANDARDIZATION AND MULTIPLICATIVE MODELS FOR RATES, WITH REFERENCE TO AGE ADJUSTMENT OF CANCER INCIDENCE AND RELATIVE FREQUENCY DATA [J].
BRESLOW, NE ;
DAY, NE .
JOURNAL OF CHRONIC DISEASES, 1975, 28 (5-6) :289-303
[3]   MODELS FOR TEMPORAL VARIATION IN CANCER RATES .1. AGE PERIOD AND AGE COHORT MODELS [J].
CLAYTON, D ;
SCHIFFLERS, E .
STATISTICS IN MEDICINE, 1987, 6 (04) :449-467
[4]   Marginal regression models for clustered ordinal measurements [J].
Heagerty, PJ ;
Zeger, SL .
JOURNAL OF THE AMERICAN STATISTICAL ASSOCIATION, 1996, 91 (435) :1024-1036
[6]   Building marginal models for multiple ordinal measurements [J].
Huang, GH ;
Bandeen-Roche, K ;
Rubin, GS .
JOURNAL OF THE ROYAL STATISTICAL SOCIETY SERIES C-APPLIED STATISTICS, 2002, 51 :37-57
[7]   A randomized, placebo-controlled, clinical trial of high-dose supplementation with vitamins C and E, beta carotene, and zinc for age-related macular degeneration and vision loss - AREDS Report No. 8 [J].
Kassoff, A ;
Kassoff, J ;
Buehler, J ;
Eglow, M ;
Kaufman, F ;
Mehu, M ;
Kieval, S ;
Mairs, M ;
Graig, B ;
Quattrocchi, A ;
Jones, D ;
Locatelli, J ;
Ruby, A ;
Capone, A ;
Garretson, B ;
Hassan, T ;
Trese, MT ;
Williams, GA ;
Regan, V ;
Manatrey, P ;
Streasick, P ;
Szydlowski, L ;
McIver, F ;
Bridges, C ;
Stanley, C ;
Cumming, K ;
Lewis, B ;
Zajechowski, M ;
Margherio, RR ;
Cox, MS ;
Camille, J ;
Falk, R ;
Siedlak, P ;
Neubert, C ;
Klein, ML ;
Stout, JT ;
O'Malley, A ;
Lauer, AK ;
Robertson, JE ;
Wilson, DJ ;
Beardsley, C ;
Anderson, H ;
Wallace, P ;
Smith, G ;
Howard, S ;
Dreyer, RF ;
Ma, C ;
Chenoweth, RG ;
Zilis, JD ;
Johnson, M .
ARCHIVES OF OPHTHALMOLOGY, 2001, 119 (10) :1417-1436
[8]  
Klein R, 1998, AM J EPIDEMIOL, V147, P103
[9]   The five-year incidence and progression of age-related maculopathy - The Beaver Dam eye study [J].
Klein, R ;
Klein, BEK ;
Jensen, SC ;
Meuer, SM .
OPHTHALMOLOGY, 1997, 104 (01) :7-21
[10]  
KLEIN R, 1992, OPHTHALMOLOGY, V99, P933