Nerve growth factor improves evoked potentials and long-term potentiation in the dentate gyrus of presenile rats

被引:16
作者
Bergado, JA [1 ]
Gómez-Soria, AA [1 ]
Cruz, R [1 ]
Fernández, CI [1 ]
机构
[1] Ctr Int Restaurac Neurol, La Habana 12100, Cuba
关键词
NGF (nerve growth factor); evoked potential; long-term potentiation;
D O I
10.1016/S0014-2999(98)00092-2
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
Chronic infusion of nerve growth factor (NGF, 1.2 mu g/day) for 14 days to presenile rats (17 months at the beginning of treatment) that showed an initial cognitive impairment led to an improved long-term potentiation in the dentate gyrus. Both the relative increase of the slope of the population excitatory postsynaptic potential and that of the population spike were enhanced by NGF pretreatment after long-term potentiation induction at 400 Hz. The treatment was also able to increase the diminished baseline amplitude of the population spike, an effect not seen when the treatment was applied to older animals [Bergado, J., Femandez, C.I., Gomez-Soria, A., Gonzalez, O., 1997a. Chronic intraventricular infusion with NGF improves LTP in old cognitively-impaired rats. Brain Res. 770, 1-9] stressing the importance of an early start of trophic therapy to achieve better results. (C) 1998 Elsevier Science B.V.
引用
收藏
页码:181 / 184
页数:4
相关论文
共 20 条
[1]   NORMAL AGING - REGIONALLY SPECIFIC CHANGES IN HIPPOCAMPAL SYNAPTIC TRANSMISSION [J].
BARNES, CA .
TRENDS IN NEUROSCIENCES, 1994, 17 (01) :13-18
[2]   THE CHOLINERGIC HYPOTHESIS OF GERIATRIC MEMORY DYSFUNCTION [J].
BARTUS, RT ;
DEAN, RL ;
BEER, B ;
LIPPA, AS .
SCIENCE, 1982, 217 (4558) :408-417
[3]  
Bergado J. A., 1996, Biological Research, V29, P197
[4]   Chronic intraventricular infusion with NGF improves LTP in old cognitively-impaired rats [J].
Bergado, JA ;
Fernandez, CI ;
GomezSoria, A ;
Gonzalez, O .
BRAIN RESEARCH, 1997, 770 (1-2) :1-9
[5]  
Bergado Jorge A., 1997, Journal of Neural Transplantation and Plasticity, V6, P31
[6]   LONG-LASTING POTENTIATION OF SYNAPTIC TRANSMISSION IN DENTATE AREA OF ANESTHETIZED RABBIT FOLLOWING STIMULATION OF PERFORANT PATH [J].
BLISS, TVP ;
LOMO, T .
JOURNAL OF PHYSIOLOGY-LONDON, 1973, 232 (02) :331-356
[7]   A SYNAPTIC MODEL OF MEMORY - LONG-TERM POTENTIATION IN THE HIPPOCAMPUS [J].
BLISS, TVP ;
COLLINGRIDGE, GL .
NATURE, 1993, 361 (6407) :31-39
[8]   ABSENCE OF LONG-TERM POTENTIATION IN THE SUBCORTICALLY DEAFFERENTED DENTATE GYRUS [J].
BUZSAKI, G ;
GAGE, FH .
BRAIN RESEARCH, 1989, 484 (1-2) :94-101
[9]   Expression of messenger RNA coding for the nerve growth factor receptor trkA in the hippocampus of the adult rat [J].
Cellerino, A .
NEUROSCIENCE, 1996, 70 (03) :613-616
[10]   NEURORESTORATIVE TECHNIQUES AS EXPERIMENTAL APPROACH TO ALZHEIMER-DISEASE TREATMENT [J].
FERNANDEZ, CI ;
SOTO, J ;
GONZALEZ, O ;
GONZALEZ, ME ;
QUIJANO, Z .
MOLECULAR AND CHEMICAL NEUROPATHOLOGY, 1995, 24 (2-3) :241-244