Anti-oxidant strategies

被引：112

作者：

Buonocore, Giuseppe

Groenendaal, Floris

机构：

[1] Univ Siena, Dept Pediat Obstet & Reprod Med, I-53100 Siena, Italy

[2] Univ Utrecht, Med Ctr, Wilhelmina Childrens Hosp, Dept Neonatol, Utrecht, Netherlands

来源：

SEMINARS IN FETAL & NEONATAL MEDICINE | 2007年 / 12卷 / 04期

关键词：

brain; free radicals; hypoxia-ischemia; neonate; neuroprotection; reactive nitrogen species; reactive oxygen species;

D O I：

10.1016/j.siny.2007.01.020

中图分类号：

R72 [儿科学];

学科分类号：

100202 ;

摘要：

Oxidative stress plays an important role in causing organ injury in the compromised fetus and neonate. Recent experimental research and clinical studies have clarified important pathways in the production of reactive oxygen and nitrogen species. Free radicals are involved in causing cerebral damage after perinatal hypoxia-ischemia affecting membrane lipids, proteins, and DNA. Anti-oxidant strategies can be used as add-on neuroprotective therapy after perinatal oxidative stress. Selective inhibitors of neuronal and inducible nitric oxide synthase, allopurinol, melatonin, and erythropoietin are among the first compounds that are ready for clinical trials. (C) 2007 Elsevier Ltd. All rights reserved.

引用

收藏

页码：287 / 295

页数：9

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