Genome regulation by polycomb and trithorax proteins

被引：1106

作者：

Schuettengruber, Bernd

Chourrout, Daniel

Vervoort, Michel

Leblanc, Benjamin

Cavalli, Giacomo

机构：

[1] CNRS, Inst Human Genet, F-34396 Montpellier 5, France

[2] Univ Bergen, Sars Int Ctr Marine Mol Biol, N-5008 Bergen, Norway

[3] CNRS, Ctr Mol Genet, UPR 2167, F-91198 Gif Sur Yvette, France

[4] Univ Paris 07, UFR Biol & Sci Nat, F-75251 Paris 05, France

来源：

CELL | 2007年 / 128卷 / 04期

关键词：

D O I：

10.1016/j.cell.2007.02.009

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Polycomb group (PcG) and trithorax group (trxG) proteins are critical regulators of numerous developmental genes. To silence or activate gene expression, respectively, PcG and trxG proteins bind to specific regions of DNA and direct the posttranslational modification of histones. Recent work suggests that PcG proteins regulate the nuclear organization of their target genes and that PcG-mediated gene silencing involves noncoding RNAs and the RNAi machinery. © 2007 Elsevier Inc. All rights reserved.

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收藏

页码：735 / 745

页数：11

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