S100A4 and Metastasis A Small Actor Playing Many Roles

被引：347

作者：

Boye, Kjetil ^{[1
,2
]}

Maelandsmo, Gunhild M. ^{[1
]}

机构：

[1] Oslo Univ Hosp, Inst Canc Res, Dept Tumor Biol, Norwegian Radium Hosp, N-0310 Oslo, Norway

[2] Oslo Univ Hosp, Dept Oncol, Norwegian Radium Hosp, N-0310 Oslo, Norway

来源：

AMERICAN JOURNAL OF PATHOLOGY | 2010年 / 176卷 / 02期

关键词：

CALCIUM-BINDING PROTEIN; EPITHELIAL-MESENCHYMAL TRANSITION; HUMAN BREAST-CANCER; TUMOR PROGRESSION; PROGNOSTIC-SIGNIFICANCE; CELLULAR-LOCALIZATION; EXTRACELLULAR S100A4; COLORECTAL-CANCER; ENDOTHELIAL-CELLS; MYOSIN-IIA;

D O I：

10.2353/ajpath.2010.090526

中图分类号：

R36 [病理学];

学科分类号：

100104 ;

摘要：

The calcium-binding protein S100A4 promotes metastasis in several experimental animal models, and S100A4 protein expression is associated with patient outcome in a number of tumor types. S100A4 is localized in the nucleus, cytoplasm, and extracellular space and possesses a wide range of biological functions, such as regulation of angiogenesis, cell survival, motility, and invasion. In this review, we summarize the evidence connecting S100A4 and cancer metastasis and discuss the mechanisms by which S100A4 promotes tumor progression. (Am J Pathol 2010, 176:528-535; DOI: 10.2353/ajpath.2010.090526)

引用

页码：528 / 535

页数：8

共 58 条

[1] The metastasis-associated Mts1(S100A4) protein could act as an angiogenic factor
Ambartsumian, N
Klingelhöfer, J
Grigorian, M
Christensen, C
Kriajevska, M
Tulchinsky, E
Georgiev, G
Berezin, V
Bock, E
Rygaard, J
Cao, RH
Cao, YH
Lukanidin, E
[J]. ONCOGENE, 2001, 20 (34) : 4685 - 4695
[2] Ambartsumian NS, 1996, ONCOGENE, V13, P1621
[3] Extracellular S100A4 stimulates the migration rate of astrocytic tumor cells by modifying the organization of their actin cytoskeleton
Belot, N
Pochet, R
Heizmann, CW
Kiss, R
Decaestecker, C
[J]. BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS, 2002, 1600 (1-2): : 74 - 83
[4] Bjornland K, 1999, CANCER RES, V59, P4702
[5] Activation of NF-κB by extracellular S100A4:: Analysis of signal transduction mechanisms and identification of target genes
Boye, Kjetil
Grotterod, Ida
Aasheim, Hans-Christian
Hovig, Eivind
Maelandsmo, Gunhild M.
[J]. INTERNATIONAL JOURNAL OF CANCER, 2008, 123 (06) : 1301 - 1310
[6] Opinion - Migrating cancer stem cells - an integrated concept of malignant tumour progression
Brabletz, T
Jung, A
Spaderna, S
Hlubek, F
Kirchner, T
[J]. NATURE REVIEWS CANCER, 2005, 5 (09) : 744 - 749
[7] Expression of S100A4 by, a variety of cell types present in the tumor microenvironment of human breast cancer
Cabezon, Teresa
Celis, Julio E.
Skibshoj, Inge
Klingelhofer, Jorg
Grigorian, Mariam
Gromov, Pavel
Rank, Fritz
Myklebust, June Helen
Maelandsmo, Gunhild M.
Lukanidin, Eugene
Ambartsumian, Noona
[J]. INTERNATIONAL JOURNAL OF CANCER, 2007, 121 (07) : 1433 - 1444
[8] Characterization of Spl, AP-1, CBF and KRC binding sites and minisatellite DNA as functional elements of the metastasis-associated mts1/S100A4 gene intronic enhancer
Cohn, MA
Hjelmso, T
Wu, LC
Guldberg, P
Lukanidin, EM
Tulchinsky, EM
[J]. NUCLEIC ACIDS RESEARCH, 2001, 29 (16) : 3335 - 3346
[9] DAVIES BR, 1993, ONCOGENE, V8, P999
[10] Davies MPA, 1996, ONCOGENE, V13, P1631

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