Stereoselective synthesis and absolute configuration of (1′R,3R,4R)-4-acetoxy-3-(2′,2′,2′-trifluoro-1′-hydroxyethyl)-azetidin-2-one

被引：14

作者：

Antolini, L ^{[1
]}

Forni, A ^{[1
]}

Davoli, P ^{[1
]}

Moretti, I ^{[1
]}

Prati, F ^{[1
]}

机构：

[1] Univ Modena, Dipartimento Chim, I-41100 Modena, Italy

来源：

TETRAHEDRON-ASYMMETRY | 1998年 / 9卷 / 02期

关键词：

D O I：

10.1016/S0957-4166(97)00640-X

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

The title compound 3, an intermediate in the synthesis of fluorocarbapenems, is obtained with high stereocontrol by the condensation of (R)-(+)-ethyl 4,4,4-trifluoro-3-hydroxybutanoate with N-trimethylsilyl cinnamylidenimine. X-Ray diffraction analysis of the condensation product and chemical correlations allowed the unambiguous determination of the absolute configuration. (C) 1998 Elsevier Science Ltd. All rights reserved.

引用

页码：285 / 292

页数：8

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