Highly efficient threonine-derived organocatalysts for direct asymmetric aldol reactions in water

被引：201

作者：

Wu, Xiaoyu

Jiang, Zhaoqin

Shen, Han-Ming

Lu, Yixin

机构：

[1] Natl Univ Singapore, Dept Chem, Singapore 117543, Singapore

[2] Natl Univ Singapore, Off Life Sci, Med Chem Program, Singapore 117543, Singapore

[3] Natl Univ Singapore, Dept Community Occupat & Family Med, Singapore 117543, Singapore

来源：

ADVANCED SYNTHESIS & CATALYSIS | 2007年 / 349卷 / 06期

关键词：

aldol reaction; asymmetric catalysis; hydrophobic effect; organic catalysis; water;

D O I：

10.1002/adsc.200600564

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

The introduction of siloxy groups at the hydroxy function of natural threonine resulted in efficient hydrophobic organocatalysts, which could efficiently catalyze the direct aldol reactions of both cyclic and acyclic ketones with aromatic aldehydes in water with excellent enantiomeric excess.

引用

页码：812 / 816

页数：5

共 46 条

[1]

[Anonymous], 2004, MODERN ALDOL REACTIO

[2]

[Anonymous], 2004, MODERN ALDOL REACTIO

[3] Immune versus natural selection: Antibody aldolases with enzymic rates but broader scope [J].